NP_001028216.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,064 Da
NCBI Official Full Name
glutamine synthetase
NCBI Official Synonym Full Names
glutamate-ammonia ligase
NCBI Protein Information
glutamine synthetase; glutamine synthase; glutamate decarboxylase; glutamate--ammonia ligase; proliferation-inducing protein 43; cell proliferation-inducing protein 59
UniProt Protein Name
Glutamine synthetase
UniProt Synonym Protein Names
Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase
UniProt Synonym Gene Names
UniProt Entry Name
GLNA_HUMAN
NCBI Summary for GS
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for GS
GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family.
Protein type: Amino Acid Metabolism - arginine and proline; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: protein complex; rough endoplasmic reticulum; mitochondrion; cytoplasm; perikaryon; nerve terminal; cytosol; nucleus
Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding
Biological Process: cell proliferation; synaptic transmission; glutamate catabolic process; glutamine biosynthetic process; response to glucose stimulus; neurotransmitter uptake; positive regulation of insulin secretion; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization
Disease: Glutamine Deficiency, Congenital
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Products associated with GS elisa kit
Pathways associated with GS elisa kit
Diseases associated with GS elisa kit
Organs/Tissues associated with GS elisa kit
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