AAA58617.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,544 Da
NCBI Official Full Name
granulin
NCBI Official Synonym Full Names
granulin
NCBI Official Synonym Symbols
GEP; GP88; PEPI; PGRN; CLN11; PCDGF [Similar Products]
NCBI Protein Information
granulins; acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor
UniProt Protein Name
Granulins
UniProt Synonym Protein Names
Proepithelin; PEPICleaved into the following 9 chains:AcrograninParagranulinGranulin-1; Alternative name(s):; Granulin GGranulin-2; Alternative name(s):; Granulin FGranulin-3; Alternative name(s):; Granulin BGranulin-4; Alternative name(s):; Granulin AGranulin-5; Alternative name(s):; Granulin CGranulin-6; Alternative name(s):; Granulin DGranulin-7; Alternative name(s):; Granulin E
UniProt Synonym Gene Names
UniProt Entry Name
GRN_HUMAN
NCBI Summary for GRN
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for GRN
GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion
Molecular Function: protein binding; growth factor activity; cytokine activity
Biological Process: blastocyst hatching; signal transduction; embryo implantation; positive regulation of epithelial cell proliferation
Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with GRN elisa kit
Pathways associated with GRN elisa kit
Diseases associated with GRN elisa kit
Organs/Tissues associated with GRN elisa kit
|