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HBH elisa kit :: Horse Hemoglobin H ELISA Kit

Scan QR to view Datasheet Catalog #    MBS019793 HBH elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemoglobin H (HBH), ELISA Kit

 Also Known As   

Horse Hemoglobin H ELISA Kit

 Product Gene Name   

HBH elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    140700
 3D Structure    ModBase 3D Structure for P69905
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 Species Reactivity    Horse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HBH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HBH purchase    MBS019793 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hemoglobin H (HBH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HBH. The ELISA analytical biochemical technique of the MBS019793 kit is based on HBH antibody-HBH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HBH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HBH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HBH. It may not necessarily be applicable to this product.
 NCBI GI #    57013850
 NCBI GeneID    3040
 NCBI Accession #    P69905.2 [Other Products]
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 UniProt Primary Accession #    P69905 [Other Products]
 UniProt Secondary Accession #    P01922; Q1HDT5; Q3MIF5; Q53F97; Q96KF1; Q9NYR7; Q9UCM0 [Other Products]
 UniProt Related Accession #    P69905 [Other Products]
 Molecular Weight    15,258 Da
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 NCBI Official Full Name    Hemoglobin subunit alpha
 NCBI Official Synonym Full Names    hemoglobin, alpha 2
 NCBI Official Symbol    HBA2 [Similar Products]
 NCBI Official Synonym Symbols   
HBH; HBA-T2
[Similar Products]
 NCBI Protein Information    hemoglobin subunit alpha; alpha globin; alpha-globin; alpha-2 globin; hemoglobin alpha chain
 UniProt Protein Name    Hemoglobin subunit alpha
 UniProt Synonym Protein Names   
Alpha-globin; Hemoglobin alpha chain
 Protein Family    Hemoglobin
 UniProt Gene Name    HBA1 [Similar Products]
 UniProt Entry Name    HBA_HUMAN
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 NCBI Summary for HBH    The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HBH    HBA1: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBA1 may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBA1 are the cause of alpha-thalassemia (A- THAL). The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non- deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers. Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non- immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders. Defects in HBA1 are the cause of hemoglobin H disease (HBH). HBH is a form of alpha-thalassemia due to the loss of three alpha genes. This results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia. Untreated, most patients die in childhood or early adolescence. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: membrane; hemoglobin complex; extracellular region; cytosol

Molecular Function: haptoglobin binding; protein binding; peroxidase activity; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; bicarbonate transport; hydrogen peroxide catabolic process; oxygen transport; protein heterooligomerization

Disease: Hemoglobin H Disease; Heinz Body Anemias; Alpha-thalassemia
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 Research Articles on HBH    1. study describes 4 rare nondeletional alpha-thalassemia mutations in Thai individuals, including initiation codon mutation (HBA2:c.1delA), donor splice site mutation (IVSI-1, HBA1:c.95 + 1G>A), Hb Queens Park (HBA1:c.98T>A) [alpha32(B13)Met>Lys], and Hb Westmead (HBA2:c.369C>G) [alpha122(H5)His>Gln
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HBH elisa kitPathways associated with HBH elisa kit
 Reference Product  PubMed Publications
 HBA1 elisa kit  >51 publications with HBH and HBA1
 HBB elisa kit  >23 publications with HBH and HBB
 HBD elisa kit  >19 publications with HBH and HBD
 HBG2 elisa kit  >5 publications with HBH and HBG2
 CD34 elisa kit  >2 publications with HBH and CD34
 HBE1 elisa kit  >1 publications with HBH and HBE1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 O2/CO2 Exchange In Erythrocytes Pathway antibodies  O2/CO2 Exchange In Erythrocytes Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
Diseases associated with HBH elisa kitOrgans/Tissues associated with HBH elisa kit
 Disease Name  Pubmed Publications
 Anemia Antibodies  >319 publications with HBH and Anemia
 alpha-Thalassemia Antibodies  >153 publications with HBH and alpha-Thalassemia
 Neoplasms Antibodies  >10 publications with HBH and Neoplasms
 Hypertrophy Antibodies  >6 publications with HBH and Hypertrophy
 Hyperplasia Antibodies  >6 publications with HBH and Hyperplasia
 Necrosis Antibodies  >5 publications with HBH and Necrosis
 Inflammation Antibodies  >4 publications with HBH and Inflammation
 Kidney Diseases Antibodies  >4 publications with HBH and Kidney Diseases
 Heart Diseases Antibodies  >4 publications with HBH and Heart Diseases
 Carcinoma Antibodies  >4 publications with HBH and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >273 publications with HBH and Blood
 Bone Antibodies  >19 publications with HBH and Bone
 Bone Marrow Antibodies  >12 publications with HBH and Bone Marrow
 Liver Antibodies  >10 publications with HBH and Liver
 Heart Antibodies  >7 publications with HBH and Heart
 Vascular Antibodies  >7 publications with HBH and Vascular
 Eye Antibodies  >7 publications with HBH and Eye
 Kidney Antibodies  >4 publications with HBH and Kidney
 Spleen Antibodies  >4 publications with HBH and Spleen
 Brain Antibodies  >3 publications with HBH and Brain
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