Q13219.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
180,973 Da
NCBI Official Full Name
Pappalysin-1
NCBI Official Synonym Full Names
pregnancy-associated plasma protein A, pappalysin 1
NCBI Official Synonym Symbols
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase [Similar Products]
NCBI Protein Information
pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; pregnacy-associated plasma protein A; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease
UniProt Protein Name
Pappalysin-1
UniProt Synonym Protein Names
Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A
UniProt Synonym Gene Names
UniProt Entry Name
PAPP1_HUMAN
NCBI Summary for PAPP-A
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
UniProt Comments for PAPP-A
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.
Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.24.79
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: membrane; extracellular region
Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis
Research Articles on PAPP-A
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Products associated with PAPP-A elisa kit
Pathways associated with PAPP-A elisa kit
Diseases associated with PAPP-A elisa kit
Organs/Tissues associated with PAPP-A elisa kit
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