NP_941372.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,548 Da
NCBI Official Full Name
rap guanine nucleotide exchange factor 1 isoform b
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor (GEF) 1
NCBI Official Synonym Symbols
NCBI Protein Information
rap guanine nucleotide exchange factor 1; CRK SH3-binding GNRP; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
UniProt Protein Name
Rap guanine nucleotide exchange factor 1
UniProt Synonym Protein Names
CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G
UniProt Synonym Gene Names
UniProt Entry Name
RPGF1_HUMAN
NCBI Summary for RAPGEF1
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for RAPGEF1
RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.
Protein type: GEFs, Ras; GEFs; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: early endosome; cytosol; endosome
Molecular Function: protein binding; Rap guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process: blood vessel development; cell-cell adhesion; negative regulation of protein kinase B signaling cascade; activation of MAPKK activity; nerve growth factor receptor signaling pathway; negative regulation of Ras protein signal transduction; platelet-derived growth factor receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; Rap protein signal transduction
Research Articles on RAPGEF1
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Products associated with RAPGEF1 elisa kit
Pathways associated with RAPGEF1 elisa kit
Diseases associated with RAPGEF1 elisa kit
Organs/Tissues associated with RAPGEF1 elisa kit
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