NP_001129171.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
14-3-3 protein zeta/delta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
NCBI Official Synonym Symbols
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta [Similar Products]
NCBI Protein Information
14-3-3 protein zeta/delta
UniProt Protein Name
14-3-3 protein zeta/delta
UniProt Synonym Protein Names
Protein kinase C inhibitor protein 1; KCIP-1
UniProt Synonym Gene Names
NCBI Summary for 14-3-3 beta/zeta
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for 14-3-3 beta/zeta
14-3-3 zeta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q22.3
Cellular Component: blood microparticle; cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular exosome; extracellular space; focal adhesion; melanosome; mitochondrion; nucleoplasm; nucleus; vesicle
Molecular Function: cadherin binding; identical protein binding; ion channel binding; protein binding; protein domain specific binding; protein kinase binding; RNA binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: establishment of Golgi localization; Golgi reassembly; negative regulation of apoptosis; platelet activation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein targeting; regulation of mRNA stability; signal transduction
Research Articles on 14-3-3 beta/zeta
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Products associated with 14-3-3 beta/zeta elisa kit
Pathways associated with 14-3-3 beta/zeta elisa kit
Diseases associated with 14-3-3 beta/zeta elisa kit
Organs/Tissues associated with 14-3-3 beta/zeta elisa kit
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