NP_000029.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
adenomatous polyposis coli protein isoform b
NCBI Official Synonym Full Names
APC, WNT signaling pathway regulator
NCBI Official Synonym Symbols
GS; DP2; DP3; BTPS2; DP2.5; PPP1R46 [Similar Products]
NCBI Protein Information
adenomatous polyposis coli protein
UniProt Protein Name
Adenomatous polyposis coli protein
UniProt Synonym Protein Names
Deleted in polyposis 2.5
UniProt Synonym Gene Names
NCBI Summary for APC
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
UniProt Comments for APC
APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 5q22.2
Cellular Component: beta-catenin destruction complex; bicellular tight junction; catenin complex; cell-cell adherens junction; centrosome; cytoplasm; cytosol; kinetochore; lamellipodium; lateral plasma membrane; microtubule; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; Wnt signalosome
Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process: beta-catenin destruction complex assembly; beta-catenin destruction complex disassembly; cell adhesion; cell cycle arrest; cell migration; cellular response to DNA damage stimulus; insulin receptor signaling pathway; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of microtubule depolymerization; positive regulation of apoptosis; positive regulation of cell death; positive regulation of cell migration; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein deubiquitination; protein homooligomerization; regulation of attachment of spindle microtubules to kinetochore; regulation of microtubule-based process; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Cancer; Hepatocellular Carcinoma
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Pathways associated with APC elisa kit
Diseases associated with APC elisa kit
Organs/Tissues associated with APC elisa kit
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