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IGF1R elisa kit

Scan QR to view Datasheet Catalog #    MBS9501480 IGF1R elisa kit
Unit / Price
2x96 Wells  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF1R, ELISA Kit

★Popular Item★
 Also Known As   

Phospho-IGF1R (Tyr1165/Tyr1166) Colorimetric Cell-Based ELISA Kit

 Product Synonym Names    CD221; IGF1R; Insulin-like growth factor I receptor precursor; kinase IGF1R
 Product Gene Name   

IGF1R elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    X04434 mRNA
 3D Structure    ModBase 3D Structure for P08069
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 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Two 96-Well Plates
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 Samples    Researchers plate their cell line of choice
 Assay Type    Phospho Cell-Based ELISA
 Sensitivity    >=5000 cells/well
 Reactivity Note    Human: Y1165+Y1166/Y1189+Y1190, Mouse: Y1167+Y1168/Y1179+Y1180, Rat: Y1166+Y1167/Y1190+Y1191
 Detection Method    Colorimetric 450 nm
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IGF1R elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IGF1R purchase    MBS9501480 is a ready-to-use microwell, strip-or-full plate Phospho Cell-Based ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IGF1R, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IGF1R, with an estimated sensitivity of >=5000 cells/well. The ELISA analytical biochemical technique of the MBS9501480 kit is based on IGF1R antibody-IGF1R antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IGF1R antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IGF1R. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Researchers plate their cell line of choice. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for IGF1R elisa kit    Cell Based ELISA Kit
Sample Manual Insert of MBS9501480. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IGF1R. It may not necessarily be applicable to this product.
 NCBI GI #    4557665
 NCBI GeneID    3480
 NCBI Accession #    NP_000866.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000875.4 [Other Products]
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 UniProt Primary Accession #    P08069 [Other Products]
 UniProt Secondary Accession #    Q14CV2; Q9UCC0; B1B5Y2 [Other Products]
 UniProt Related Accession #    P08069 [Other Products]
 Molecular Weight    154793
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 NCBI Official Full Name    insulin-like growth factor 1 receptor isoform 1
 NCBI Official Synonym Full Names    insulin like growth factor 1 receptor
 NCBI Official Symbol    IGF1R [Similar Products]
 NCBI Official Synonym Symbols   
IGFR; CD221; IGFIR; JTK13
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 1 receptor
 UniProt Protein Name    Insulin-like growth factor 1 receptor
 UniProt Synonym Protein Names   
Insulin-like growth factor I receptor; IGF-I receptor
 Protein Family    Insulin-like growth factor 1 receptor
 UniProt Gene Name    IGF1R [Similar Products]
 UniProt Synonym Gene Names    IGF-I receptor [Similar Products]
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 NCBI Summary for IGF1R    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
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 UniProt Comments for IGF1R    IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: integral component of plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor-activated receptor activity; phosphoinositide 3-kinase binding; protein binding; protein tyrosine kinase activity

Biological Process: cellular response to amyloid-beta; immune response; inactivation of MAPKK activity; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptosis; peptidyl-tyrosine autophosphorylation; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of protein complex disassembly; protein autophosphorylation; protein tetramerization; regulation of JNK cascade; signal transduction

Disease: Insulin-like Growth Factor I, Resistance To
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 Research Articles on IGF1R    1. Results show a significant over-expression of EGFR and IGF1R in adrenocortical carcinoma (ACC) tissue.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF1R elisa kitPathways associated with IGF1R elisa kit
 Reference Product  PubMed Publications
 IGF1 elisa kit  >324 publications with IGF1R and IGF1
 IGFBP3 elisa kit  >250 publications with IGF1R and IGFBP3
 IRS1 elisa kit  >222 publications with IGF1R and IRS1
 IGF2 elisa kit  >133 publications with IGF1R and IGF2
 SRC elisa kit  >132 publications with IGF1R and SRC
 IRS2 elisa kit  >83 publications with IGF1R and IRS2
 INSR elisa kit  >65 publications with IGF1R and INSR
 STAT3 elisa kit  >38 publications with IGF1R and STAT3
 SHC1 elisa kit  >34 publications with IGF1R and SHC1
 GRB10 elisa kit  >23 publications with IGF1R and GRB10
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
Diseases associated with IGF1R elisa kitOrgans/Tissues associated with IGF1R elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1911 publications with IGF1R and Neoplasms
 Breast Neoplasms Antibodies  >417 publications with IGF1R and Breast Neoplasms
 Adenocarcinoma Antibodies  >283 publications with IGF1R and Adenocarcinoma
 Insulin-Like Growth Factor I, Resistance To Antibodies  >229 publications with IGF1R and Insulin-Like Growth Factor I, Resistance To
 Neoplasms, Experimental Antibodies  >224 publications with IGF1R and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >203 publications with IGF1R and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >197 publications with IGF1R and Nervous System Diseases
 Lung Neoplasms Antibodies  >177 publications with IGF1R and Lung Neoplasms
 Growth Disorders Antibodies  >170 publications with IGF1R and Growth Disorders
 Lung Diseases Antibodies  >147 publications with IGF1R and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >240 publications with IGF1R and Lung
 Ovary Antibodies  >160 publications with IGF1R and Ovary
 Eye Antibodies  >91 publications with IGF1R and Eye
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