NP_056007.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
133,703 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a
NCBI Official Synonym Full Names
phospholipase C, beta 1 (phosphoinositide-specific)
NCBI Official Synonym Symbols
PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154 [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-beta-1; phospholipase C-I; phosphoinositidase C; inositoltrisphosphohydrolase; triphosphoinositide phosphodiesterase; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
UniProt Synonym Protein Names
PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1
UniProt Synonym Gene Names
UniProt Entry Name
PLCB1_HUMAN
NCBI Summary for PLCB1
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PLCB1
PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: nuclear membrane; cytoplasm; nuclear chromatin; nuclear speck; nucleus; cytosol
Molecular Function: calmodulin binding; signal transducer activity; phosphatidylinositol-4,5-bisphosphate binding; enzyme binding; protein homodimerization activity; calcium ion binding; phosphoinositide phospholipase C activity; GTPase activator activity; lamin binding
Biological Process: fat cell differentiation; positive regulation of developmental growth; acetylcholine receptor signaling, muscarinic pathway; inositol phosphate metabolic process; positive regulation of interleukin-12 production; glutamate signaling pathway; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; signal transduction; memory; positive regulation of myoblast differentiation; synaptic transmission; positive regulation of embryonic development; insulin-like growth factor receptor signaling pathway; cerebral cortex development; phosphatidylinositol metabolic process; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle; lipid catabolic process; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Disease: Epileptic Encephalopathy, Early Infantile, 12
Research Articles on PLCB1
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Pathways associated with PLCB1 elisa kit
Diseases associated with PLCB1 elisa kit
Organs/Tissues associated with PLCB1 elisa kit
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