NP_001027581.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,944 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 1 isoform 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 1
NCBI Protein Information
2'-5'-oligoadenylate synthase 1
UniProt Protein Name
2'-5'-oligoadenylate synthase 1
UniProt Synonym Protein Names
E18/E16; p46/p42 OAS
UniProt Synonym Gene Names
NCBI Summary for OAS1
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
UniProt Comments for OAS1
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Research Articles on OAS1
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Products associated with OAS1 elisa kit
Pathways associated with OAS1 elisa kit
Diseases associated with OAS1 elisa kit
Organs/Tissues associated with OAS1 elisa kit
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