NP_660262.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,285 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 2
NCBI Official Synonym Full Names
2'-5' oligoadenylate synthetase 2
NCBI Official Synonym Symbols
NCBI Protein Information
2'-5'-oligoadenylate synthase 2
UniProt Protein Name
2'-5'-oligoadenylate synthase 2
UniProt Synonym Protein Names
2',5'-oligoadenylate synthetase-like 11
UniProt Synonym Gene Names
UniProt Entry Name
OAS2_MOUSE
UniProt Comments for OAS2
OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.7.84
Cellular Component: cytoplasm; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function: 2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; RNA binding; transferase activity; zinc ion binding
Biological Process: defense response to virus; immune response; immune system process; innate immune response; protein amino acid glycosylation; protein myristoylation; purine nucleotide biosynthetic process; response to virus; RNA catabolic process
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Products associated with OAS2 elisa kit
Pathways associated with OAS2 elisa kit
Diseases associated with OAS2 elisa kit
Organs/Tissues associated with OAS2 elisa kit
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