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DHCR24 elisa kit :: Human 24-dehydrocholesterol reductase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9328939 DHCR24 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

24-dehydrocholesterol reductase (DHCR24), ELISA Kit

 Also Known As   

Human Delta (24) -sterol reductase, DHCR24 ELISA Kit

 Product Synonym Names    Human Delta (24) -sterol reductase (DHCR24) ELISA kit; KIAA0018; Nbla03646; SELADIN1; seladin-1; 3 beta-hydroxysterol delta 24-reductase; diminuto/dwarf1 homolog; putative protein product of Nbla03646; selective AD indicator 1; 24-dehydrocholesterol reductase
 Product Gene Name   

DHCR24 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    606418
 3D Structure    ModBase 3D Structure for Q15392
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.25 ng/ml - 8 ng/ml.
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DHCR24 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DHCR24 purchase    MBS9328939 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 24-dehydrocholesterol reductase (DHCR24) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing DHCR24, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS9328939 kit is based on DHCR24 antibody-DHCR24 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DHCR24 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DHCR24. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for DHCR24 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DHCR24 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9328939. Click to request current manual
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NCBI/Uniprot data below describe general gene information for DHCR24. It may not necessarily be applicable to this product.
 NCBI GI #    13375618
 NCBI GeneID    1718
 NCBI Accession #    NP_055577.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014762.3 [Other Products]
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 UniProt Primary Accession #    Q15392 [Other Products]
 UniProt Secondary Accession #    Q9HBA8; D3DQ51 [Other Products]
 UniProt Related Accession #    Q15392 [Other Products]
 Molecular Weight    60,101 Da
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 NCBI Official Full Name    delta(24)-sterol reductase
 NCBI Official Synonym Full Names    24-dehydrocholesterol reductase
 NCBI Official Symbol    DHCR24 [Similar Products]
 NCBI Official Synonym Symbols   
DCE; SELADIN1; Nbla03646; seladin-1
[Similar Products]
 NCBI Protein Information    delta(24)-sterol reductase; delta(24)-sterol reductase; seladin 1; diminuto/dwarf1 homolog; selective AD indicator 1; desmosterol-to-cholesterol enzyme; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase
 UniProt Protein Name    Delta(24)-sterol reductase
 UniProt Synonym Protein Names   
24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1
 Protein Family    Delta(24)-sterol reductase
 UniProt Gene Name    DHCR24 [Similar Products]
 UniProt Synonym Gene Names    KIAA0018 [Similar Products]
 UniProt Entry Name    DHC24_HUMAN
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 NCBI Summary for DHCR24    This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DHCR24    Diminuto: the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth.

Protein type: EC 1.3.1.72; Membrane protein, integral; Lipid Metabolism - steroid biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cytoskeleton; membrane; endoplasmic reticulum; integral to membrane; nucleus; cytosol

Molecular Function: delta24(24-1) sterol reductase activity; UDP-N-acetylmuramate dehydrogenase activity; enzyme binding; peptide antigen binding; FAD binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; delta24-sterol reductase activity

Biological Process: skin development; tissue development; apoptosis; response to hormone stimulus; negative regulation of caspase activity; cholesterol biosynthetic process; negative regulation of cell proliferation; protein localization; amyloid precursor protein catabolic process; Ras protein signal transduction; male genitalia development; response to oxidative stress; cell cycle arrest; plasminogen activation; negative regulation of apoptosis

Disease: Desmosterolosis
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 Research Articles on DHCR24    1. TR-beta and LXR-alpha competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DHCR24 elisa kitPathways associated with DHCR24 elisa kit
 Reference Product  PubMed Publications
 TP53 elisa kit  >2 publications with DHCR24 and TP53
 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram
 Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway antibodies  Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway Diagram
Organs/Tissues associated with DHCR24 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >61 publications with DHCR24 and Nerve
 Brain Antibodies  >32 publications with DHCR24 and Brain
 Blood Antibodies  >13 publications with DHCR24 and Blood
 Liver Antibodies  >10 publications with DHCR24 and Liver
 Prostate Antibodies  >9 publications with DHCR24 and Prostate
 Skin Antibodies  >6 publications with DHCR24 and Skin
 Embryonic Tissue Antibodies  >5 publications with DHCR24 and Embryonic Tissue
 Adrenal Gland Antibodies  >5 publications with DHCR24 and Adrenal Gland
 Vascular Antibodies  >3 publications with DHCR24 and Vascular
 Thyroid Antibodies  >3 publications with DHCR24 and Thyroid
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