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PSMC5 elisa kit :: Human 26S protease regulatory subunit 8 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7236697 PSMC5 elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

26S protease regulatory subunit 8 (PSMC5), ELISA Kit

 Also Known As   

Human 26S protease regulatory subunit 8 ELISA Kit

 Product Gene Name   

PSMC5 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    601681
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    0.5-10ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PSMC5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PSMC5 purchase    MBS7236697 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 26S protease regulatory subunit 8 (PSMC5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5-10ng/mL in biological research samples containing PSMC5, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS7236697 kit is based on PSMC5 antibody-PSMC5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PSMC5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PSMC5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PSMC5 elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for PSMC5. It may not necessarily be applicable to this product.
 NCBI GI #    312596881
 NCBI GeneID    5705
 NCBI Accession #    NP_001186092.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199163.1 [Other Products]
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 UniProt Secondary Accession #    O35051; O43208; P47210; P52915; P52916; A8K3Z3; A8K763 [Other Products]
 UniProt Related Accession #    P62195 [Other Products]
 Molecular Weight    44,784 Da
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 NCBI Official Full Name    26S protease regulatory subunit 8 isoform 2
 NCBI Official Synonym Full Names    proteasome (prosome, macropain) 26S subunit, ATPase, 5
 NCBI Official Symbol    PSMC5 [Similar Products]
 NCBI Official Synonym Symbols   
S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG
[Similar Products]
 NCBI Protein Information    26S protease regulatory subunit 8; MSUG1 protein; proteasome subunit p45; thyroid receptor interactor 1; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; proteasome 26S subunit ATPase 5; 26S proteasome AAA-ATPase subunit RPT6; thyroid hormone receptor-interacting protein 1
 UniProt Protein Name    26S protease regulatory subunit 8
 UniProt Synonym Protein Names   
26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUG
 Protein Family    26S protease regulatory
 UniProt Gene Name    PSMC5 [Similar Products]
 UniProt Synonym Gene Names    SUG1; TRIP1 [Similar Products]
 UniProt Entry Name    PRS8_HUMAN
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 NCBI Summary for PSMC5    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for PSMC5    RPT6: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family.

Protein type: Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; cytoplasm; cytoplasmic vesicle; inclusion body; cytosol; nucleus

Molecular Function: thyrotropin-releasing hormone receptor binding; protein binding; TATA-binding protein binding; ATPase activity; transcription cofactor activity; transcription factor binding; ATP binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; positive regulation of transcription, DNA-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of programmed cell death; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; negative regulation of transcription, DNA-dependent; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
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 Research Articles on PSMC5    1. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMC5 elisa kitPathways associated with PSMC5 elisa kit
 Reference Product  PubMed Publications
 PSMC2 elisa kit  >2 publications with PSMC5 and PSMC2
 PSMC3 elisa kit  >2 publications with PSMC5 and PSMC3
 PSMD1 elisa kit  >1 publications with PSMC5 and PSMD1
 PSMD2 elisa kit  >1 publications with PSMC5 and PSMD2
 PSMC4 elisa kit  >1 publications with PSMC5 and PSMC4
 PSMC1 elisa kit  >1 publications with PSMC5 and PSMC1
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
Diseases associated with PSMC5 elisa kitOrgans/Tissues associated with PSMC5 elisa kit
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with PSMC5 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with PSMC5 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with PSMC5 and Liver Diseases
 Disease Models, Animal Antibodies  >1 publications with PSMC5 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with PSMC5 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >8 publications with PSMC5 and Thyroid
 Liver Antibodies  >3 publications with PSMC5 and Liver
 Brain Antibodies  >3 publications with PSMC5 and Brain
 Blood Antibodies  >2 publications with PSMC5 and Blood
 Bone Antibodies  >1 publications with PSMC5 and Bone
 Muscle Antibodies  >1 publications with PSMC5 and Muscle
 Bone Marrow Antibodies  >1 publications with PSMC5 and Bone Marrow
 Placenta Antibodies  >1 publications with PSMC5 and Placenta
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