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XRN2 elisa kit :: Human 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9312769 XRN2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5'-3'Exoribonuclease 2 (XRN2), ELISA Kit

 Also Known As   

Human 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit

 Product Gene Name   

XRN2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 20; NC_000020.10 (21283942..21370463). Location: 20p11.2-p11.1
 OMIM    608851
 3D Structure    ModBase 3D Structure for Q9H0D6
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of XRN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for XRN2 purchase    MBS9312769 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing XRN2. The ELISA analytical biochemical technique of the MBS9312769 kit is based on XRN2 antibody-XRN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect XRN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, XRN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for XRN2. It may not necessarily be applicable to this product.
 NCBI GI #    124297173
 NCBI GeneID    22803
 NCBI Accession #    AAI31776.1 [Other Products]
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 UniProt Primary Accession #    Q9H0D6 [Other Products]
 UniProt Secondary Accession #    Q3L8N4; Q6KGZ9; Q9BQL1; Q9NTW0; Q9NXS6; Q9UL53 [Other Products]
 UniProt Related Accession #    Q9H0D6 [Other Products]
 Molecular Weight    108,582 Da
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 NCBI Official Full Name    XRN2 protein
 NCBI Official Synonym Full Names    5'-3' exoribonuclease 2
 NCBI Official Symbol    XRN2 [Similar Products]
 NCBI Protein Information    5'-3' exoribonuclease 2; DHP protein; Dhm1-like protein (mouse homolog)
 UniProt Protein Name    5'-3' exoribonuclease 2
 UniProt Synonym Protein Names   
DHM1-like protein
 UniProt Gene Name    XRN2 [Similar Products]
 UniProt Synonym Gene Names    DHP protein [Similar Products]
 UniProt Entry Name    XRN2_HUMAN
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 NCBI Summary for XRN2    This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XRN2    XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Cell development/differentiation; Nucleolus; Ribonuclease; RNA processing; EC 3.1.13.-

Chromosomal Location of Human Ortholog: 20p11.2-p11.1

Cellular Component: membrane; nucleolus; nucleus

Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding

Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; cell growth; DNA catabolic process, exonucleolytic; mRNA processing; transcription termination
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 Research Articles on XRN2    1. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with XRN2 elisa kitPathways associated with XRN2 elisa kit
 Reference Product  PubMed Publications
 EXOSC10 elisa kit  >1 publications with XRN2 and EXOSC10
 DOM3Z elisa kit  >1 publications with XRN2 and DOM3Z
 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with XRN2 elisa kitOrgans/Tissues associated with XRN2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with XRN2 and Neoplasms
 Anemia Antibodies  >1 publications with XRN2 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with XRN2 and Lung
 Testis Antibodies  >2 publications with XRN2 and Testis
 Bone Antibodies  >1 publications with XRN2 and Bone
 Bone Marrow Antibodies  >1 publications with XRN2 and Bone Marrow
 Salivary Gland Antibodies  >1 publications with XRN2 and Salivary Gland
 Blood Antibodies  >1 publications with XRN2 and Blood
 Liver Antibodies  >1 publications with XRN2 and Liver
 Kidney Antibodies  >1 publications with XRN2 and Kidney
 Brain Antibodies  >1 publications with XRN2 and Brain
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