AAH22334.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,383 Da
NCBI Official Full Name
5', 3'-nucleotidase, cytosolic
NCBI Official Synonym Full Names
5', 3'-nucleotidase, cytosolic
NCBI Official Synonym Symbols
DNT; cdN; DNT1; P5N2; PN-I; PN-II; UMPH2; dNT-1 [Similar Products]
NCBI Protein Information
5'(3')-deoxyribonucleotidase, cytosolic type; 5'(3')-deoxyribonucleotidase, cytosolic type; deoxy-5'-nucleotidase 1; cytosolic 5',3'-pyrimidine nucleotidase; uridine 5-prime monophosphate hydrolase 2; uridine 5'-monophosphate phosphohydrolase 2; 5' nucleotidase, deoxy (pyrimidine), cytosolic type C
UniProt Protein Name
5'(3')-deoxyribonucleotidase, cytosolic type
UniProt Synonym Protein Names
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1
UniProt Synonym Gene Names
UniProt Entry Name
NT5C_HUMAN
NCBI Summary for NT5C
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for NT5C
NT5C: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Belongs to the 5'(3')-deoxyribonucleotidase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.-; Hydrolase
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotidase activity; pyrimidine nucleotide binding
Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine deoxyribonucleotide catabolic process; purine nucleotide catabolic process; purine base metabolic process
Research Articles on NT5C
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Products associated with NT5C elisa kit
Pathways associated with NT5C elisa kit
Diseases associated with NT5C elisa kit
Organs/Tissues associated with NT5C elisa kit
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