NP_000860.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,280 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 3A isoform b
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
NCBI Official Synonym Symbols
HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 3A; 5-HT3-A; serotonin receptor 3A; 5HT3 serotonin receptor; serotonin-gated ion channel receptor
UniProt Protein Name
5-hydroxytryptamine receptor 3A
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
UniProt Synonym Gene Names
UniProt Entry Name
5HT3A_HUMAN
NCBI Summary for HTR3A
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for HTR3A
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Transporter, ion channel; Membrane protein, integral; Channel, cation
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: postsynaptic membrane; cell soma; axon; integral to plasma membrane; cytoplasm; plasma membrane; cell junction
Molecular Function: serotonin binding; voltage-gated potassium channel activity; serotonin-activated cation-selective channel activity; serotonin receptor activity; receptor activity
Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway
Research Articles on HTR3A
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Pathways associated with HTR3A elisa kit
Diseases associated with HTR3A elisa kit
Organs/Tissues associated with HTR3A elisa kit
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