NP_000862.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
5-hydroxytryptamine receptor 6
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
NCBI Protein Information
5-hydroxytryptamine receptor 6; serotonin receptor 6
UniProt Protein Name
5-hydroxytryptamine receptor 6
UniProt Synonym Protein Names
Serotonin receptor 6
UniProt Synonym Gene Names
UniProt Entry Name
5HT6R_HUMAN
NCBI Summary for HTR6
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
UniProt Comments for HTR6
5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36-p35
Cellular Component: integral to plasma membrane; dendrite; plasma membrane; cilium
Molecular Function: protein binding; serotonin receptor activity; histamine receptor activity
Biological Process: response to drug; positive regulation of dopamine secretion; negative regulation of glutamate secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of acetylcholine secretion; learning; response to estradiol stimulus; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cerebral cortex cell migration; positive regulation of TOR signaling pathway; serotonin receptor signaling pathway; positive regulation of gamma-aminobutyric acid secretion
Research Articles on HTR6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with HTR6 elisa kit
Pathways associated with HTR6 elisa kit
Diseases associated with HTR6 elisa kit
Organs/Tissues associated with HTR6 elisa kit
|