NP_060040.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
137,457 Da
NCBI Official Full Name
5-oxoprolinase
NCBI Official Synonym Full Names
5-oxoprolinase (ATP-hydrolysing)
NCBI Protein Information
5-oxoprolinase
UniProt Protein Name
5-oxoprolinase
UniProt Synonym Protein Names
5-oxo-L-prolinase; 5-OPase; Pyroglutamase
UniProt Synonym Gene Names
NCBI Summary for OPLAH
The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
UniProt Comments for OPLAH
OPLAH: Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Defects in OPLAH are the cause of 5-oxoprolinase deficiency (OPLAHD). A disorder characterized by calcium oxalate/carbonate urolithiasis, and excessive urinary 5- oxo-L-proline. Affected individuals have recurrent episodes of vomiting, diarrhea, and abdominal pain. Belongs to the oxoprolinase family.
Protein type: EC 3.5.2.9; Hydrolase; Other Amino Acids Metabolism - glutathione
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cytosol
Molecular Function: 5-oxoprolinase (ATP-hydrolyzing) activity
Biological Process: glutathione biosynthetic process; glutathione metabolic process
Disease: 5-oxoprolinase Deficiency
Research Articles on OPLAH
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with OPLAH elisa kit
Pathways associated with OPLAH elisa kit
Organs/Tissues associated with OPLAH elisa kit
|