NP_620688.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,757 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 17 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 17
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Synonym Gene Names
NCBI Summary for ADAM17
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
UniProt Comments for ADAM17
ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; nucleic acid binding; zinc ion binding
Biological Process: proteolysis
Disease: Weill-marchesani-like Syndrome
Research Articles on ADAM17
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Products associated with ADAM17 elisa kit
Pathways associated with ADAM17 elisa kit
Diseases associated with ADAM17 elisa kit
Organs/Tissues associated with ADAM17 elisa kit
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