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ADAMTS8 elisa kit :: Human A Disintegrin And Metalloproteinase With Thrombospondin 8 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2533412
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8), ELISA Kit

★Popular Item★
 Also Known As   

Human ADAMTS8 (A Disintegrin And Metalloproteinase With Thrombospondin 8) ELISA Kit

 Product Gene Name   

ADAMTS8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605175
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanADAMTS8. No significant cross-reactivity or interference between HumanADAMTS8 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.313-20ng/mL
 Sensitivity    Min: 0.188ng/mL; Max: 20ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAMTS8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAMTS8 purchase    MBS2533412 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313-20ng/mL in biological research samples containing ADAMTS8, with an estimated sensitivity of Min: 0.188ng/mL; Max: 20ng/mL. The ELISA analytical biochemical technique of the MBS2533412 kit is based on ADAMTS8 antibody-ADAMTS8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ADAMTS8 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanADAMTS8concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to ADAMTS8. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ADAMTS8and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ADAMTS8, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of ADAMTS8.You can calculate the concentration of ADAMTS8in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ADAMTS8 elisa kit    ADAMTS8 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533412. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ADAMTS8. It may not necessarily be applicable to this product.
 NCBI GI #    153792351
 NCBI GeneID    11095
 NCBI Accession #    NP_008968.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_007037.5 [Other Products]
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 UniProt Secondary Accession #    Q9NZS0 [Other Products]
 UniProt Related Accession #    Q9UP79 [Other Products]
 Molecular Weight    96,460 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif 8
 NCBI Official Symbol    ADAMTS8 [Similar Products]
 NCBI Official Synonym Symbols   
METH2; ADAM-TS8
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 8
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 8
 UniProt Synonym Protein Names   
METH-2; METH-8
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS8 [Similar Products]
 UniProt Synonym Gene Names    METH2; ADAM-TS 8; ADAM-TS8; ADAMTS-8 [Similar Products]
 UniProt Entry Name    ATS8_HUMAN
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 NCBI Summary for ADAMTS8    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAMTS8    ADAMTS8: Has anti-angiogenic properties.

Protein type: Secreted; EC 3.4.24.-; Motility/polarity/chemotaxis; Cell cycle regulation; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; low affinity phosphate transmembrane transporter activity; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding

Biological Process: negative regulation of cell proliferation; proteolysis
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 Research Articles on ADAMTS8    1. Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ADAMTS8 elisa kitDiseases associated with ADAMTS8 elisa kit
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with ADAMTS8 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >3 publications with ADAMTS8 and Disease Models, Animal
 Necrosis Antibodies  >3 publications with ADAMTS8 and Necrosis
 Brain Diseases Antibodies  >2 publications with ADAMTS8 and Brain Diseases
 Lung Diseases Antibodies  >2 publications with ADAMTS8 and Lung Diseases
 Liver Diseases Antibodies  >1 publications with ADAMTS8 and Liver Diseases
 Hypertension Antibodies  >1 publications with ADAMTS8 and Hypertension
 Myocardial Infarction Antibodies  >1 publications with ADAMTS8 and Myocardial Infarction
 Inflammation Antibodies  >1 publications with ADAMTS8 and Inflammation
Organs/Tissues associated with ADAMTS8 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >4 publications with ADAMTS8 and Heart
 Brain Antibodies  >4 publications with ADAMTS8 and Brain
 Lung Antibodies  >3 publications with ADAMTS8 and Lung
 Connective Tissue Antibodies  >1 publications with ADAMTS8 and Connective Tissue
 Pancreas Antibodies  >1 publications with ADAMTS8 and Pancreas
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