NP_001280124.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,446 Da
NCBI Official Full Name
A/G-specific adenine DNA glycosylase isoform 4
NCBI Official Synonym Full Names
mutY homolog
NCBI Official Synonym Symbols
NCBI Protein Information
A/G-specific adenine DNA glycosylase
UniProt Protein Name
A/G-specific adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Synonym Gene Names
UniProt Entry Name
MUTYH_HUMAN
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MUTYH
MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Tumor suppressor; DNA repair, damage; Mitochondrial; EC 3.2.2.-
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; 4 iron, 4 sulfur cluster binding; metal ion binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutLbeta complex binding; MutSbeta complex binding; MutSalpha complex binding
Biological Process: mismatch repair; base-excision repair, AP site formation; depurination; base-excision repair; DNA repair
Disease: Gastric Cancer; Pilomatrixoma; Familial Adenomatous Polyposis, 2
Research Articles on MUTYH
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Products associated with MUTYH elisa kit
Pathways associated with MUTYH elisa kit
Diseases associated with MUTYH elisa kit
Organs/Tissues associated with MUTYH elisa kit
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