NP_955387.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,768 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 18
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 18
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 18
UniProt Synonym Gene Names
UniProt Entry Name
ATS18_HUMAN
NCBI Summary for ADAMTS18
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
UniProt Comments for ADAMTS18
ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.24.-; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q23
Cellular Component: proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; zinc ion binding
Biological Process: eye development; proteolysis
Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus
Research Articles on ADAMTS18
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Products associated with ADAMTS18 elisa kit
Pathways associated with ADAMTS18 elisa kit
Diseases associated with ADAMTS18 elisa kit
Organs/Tissues associated with ADAMTS18 elisa kit
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