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ACE2 elisa kit :: Human ACE2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS177258
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE2, ELISA Kit

 Also Known As   

Human ACE2 PicoKine ELISA Kit

 Product Synonym Names    Angiotensin-converting enzyme 2; angiotensin I converting enzyme 2; ACE 2; ACE related carboxypeptidase; ACE-related carboxypeptidase; ACE2; ACE2_HUMAN; ACEH; Angiotensin converting enzyme 2; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; Angiotensin-converting enzyme homolog; DKFZP434A014; EC 3.4.17; metalloprotease MPROT 15; Metalloprotease MPROT15; OTTHUMP00000022963; Processed angiotensin-converting enzyme 2
 Product Gene Name   

ACE2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    300335
 3D Structure    ModBase 3D Structure for Q9BYF1
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 Species Reactivity    Human
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 Specificity    Natural and recombinant human ACE2
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 Samples    Cell culture supernates, serum and plasma (heparin, EDTA)
 Assay Type    Sandwich
 Detection Range    62.5pg/ml-4000pg/ml
 Sensitivity    < 10pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACE2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACE2 purchase    MBS177258 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ACE2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5pg/ml-4000pg/ml in biological research samples containing ACE2, with an estimated sensitivity of < 10pg/ml. The ELISA analytical biochemical technique of the MBS177258 kit is based on ACE2 antibody-ACE2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACE2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACE2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ACE2 elisa kit

   Principle of the assay: human ACE2 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for ACE2 has been precoated onto 96-well plates. Standards(NSO, Q18-S740) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for ACE2 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human ACE2 amount of sample captured in plate.
Background: AngiotensinI-converting enzyme 2 (ACE 2) is a protein belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. By sequence similarity to a sequence in GenBank, this gene is mapped to Xp22.2. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
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 Typical Testing Data/Standard Curve (for reference only) of ACE2 elisa kit    Human ACE2 PicoKine ELISA Kit standard curve
ACE2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS177258. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.
 NCBI GI #    71658783
 NCBI GeneID    59272
 NCBI Accession #    Q9BYF1.2 [Other Products]
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 UniProt Primary Accession #    Q9BYF1 [Other Products]
 UniProt Secondary Accession #    Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6; C7ECU1 [Other Products]
 UniProt Related Accession #    Q9BYF1 [Other Products]
 Molecular Weight    63,912 Da
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 NCBI Official Full Name    Angiotensin-converting enzyme 2
 NCBI Official Synonym Full Names    angiotensin I converting enzyme 2
 NCBI Official Symbol    ACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ACEH
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
 UniProt Protein Name    Angiotensin-converting enzyme 2
 UniProt Synonym Protein Names   
ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15Cleaved into the following chain:Processed angiotensin-converting enzyme 2
 Protein Family    Angiotensin-converting enzyme
 UniProt Gene Name    ACE2 [Similar Products]
 UniProt Synonym Gene Names    ACEH [Similar Products]
 UniProt Entry Name    ACE2_HUMAN
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 NCBI Summary for ACE2    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACE2    ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral; EC 3.4.17.23

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; plasma membrane; extracellular region; lipid raft

Molecular Function: peptidyl-dipeptidase activity; viral receptor activity; protein binding; metallopeptidase activity; zinc ion binding; carboxypeptidase activity; peptide hormone binding; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; maternal process involved in pregnancy; regulation of vasodilation; proteolysis; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cytokine production; regulation of cell proliferation; cellular protein metabolic process; regulation of vasoconstriction; regulation of inflammatory response; angiotensin catabolic process in blood; receptor biosynthetic process; angiotensin mediated drinking behavior
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 Research Articles on ACE2    1. Data suggest angiotensin (ANG) converting enzyme 2/ANG-II-(1-7)/proto-oncogene protein Mas axis regulates inflammation/fibrosis, cell proliferation, and leukocyte recruitment/activation; main topic here is kidney/inflammatory renal disease. [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACE2 elisa kitPathways associated with ACE2 elisa kit
 Reference Product  PubMed Publications
 ACE elisa kit  >477 publications with ACE2 and ACE
 AGT elisa kit  >27 publications with ACE2 and AGT
 ATP6AP2 elisa kit  >9 publications with ACE2 and ATP6AP2
 SLC6A19 elisa kit  >8 publications with ACE2 and SLC6A19
 CMA1 elisa kit  >1 publications with ACE2 and CMA1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with ACE2 elisa kitOrgans/Tissues associated with ACE2 elisa kit
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >319 publications with ACE2 and Hypertension
 Vascular Diseases Antibodies  >232 publications with ACE2 and Vascular Diseases
 Heart Diseases Antibodies  >160 publications with ACE2 and Heart Diseases
 Kidney Diseases Antibodies  >113 publications with ACE2 and Kidney Diseases
 Hypertrophy Antibodies  >88 publications with ACE2 and Hypertrophy
 Fibrosis Antibodies  >86 publications with ACE2 and Fibrosis
 Hypertension, Renal Antibodies  >85 publications with ACE2 and Hypertension, Renal
 Heart Failure Antibodies  >82 publications with ACE2 and Heart Failure
 Inflammation Antibodies  >69 publications with ACE2 and Inflammation
 Ventricular Remodeling Antibodies  >43 publications with ACE2 and Ventricular Remodeling
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >254 publications with ACE2 and Kidney
 Muscle Antibodies  >148 publications with ACE2 and Muscle
 Brain Antibodies  >80 publications with ACE2 and Brain
 Intestine Antibodies  >19 publications with ACE2 and Intestine
 Placenta Antibodies  >15 publications with ACE2 and Placenta
 Testis Antibodies  >11 publications with ACE2 and Testis
 Mixed Antibodies  >8 publications with ACE2 and Mixed
 Eye Antibodies  >7 publications with ACE2 and Eye
 Stomach Antibodies  >4 publications with ACE2 and Stomach
 Mouth Antibodies  >1 publications with ACE2 and Mouth
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