NP_000011.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,124 Da
NCBI Official Full Name
serine/threonine-protein kinase receptor R3
NCBI Official Synonym Full Names
activin A receptor like type 1
NCBI Official Synonym Symbols
HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1 [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase receptor R3
UniProt Protein Name
Serine/threonine-protein kinase receptor R3
UniProt Synonym Protein Names
Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
UniProt Synonym Gene Names
UniProt Entry Name
ACVL1_HUMAN
NCBI Summary for ACVRL1
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
UniProt Comments for ACVRL1
ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.
Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: activin binding; activin receptor activity, type I; ATP binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I
Biological Process: angiogenesis; blood circulation; blood vessel endothelial cell proliferation during sprouting angiogenesis; blood vessel maturation; blood vessel remodeling; BMP signaling pathway; lymphangiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell adhesion; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of blood pressure; regulation of blood vessel endothelial cell migration; regulation of DNA replication; regulation of endothelial cell proliferation; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells
Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2
Research Articles on ACVRL1
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Products associated with ACVRL1 elisa kit
Pathways associated with ACVRL1 elisa kit
Diseases associated with ACVRL1 elisa kit
Organs/Tissues associated with ACVRL1 elisa kit
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