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ADAMTSL2 elisa kit :: Human ADAMTS-like 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS926864
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS-like 2 (ADAMTSL2), ELISA Kit

★Popular Item★
 Also Known As   

Human ADAMTS-like protein 2, ADAMTSL2 ELISA Kit

 Product Synonym Names    Human ADAMTS-like protein 2 (ADAMTSL2) ELISA kit; FLJ45164; KIAA0605; ; ADAMTS-like 2
 Product Gene Name   

ADAMTSL2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS926864 Testing Data    Testing Data PDF
 OMIM    612277
 3D Structure    ModBase 3D Structure for Q86TH1
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human ADAMTSL2. No significant cross-reactivity or interference between human ADAMTSL2 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Detection Range    3.12 ng/ml -200 ng/mL
 Sensitivity    <0.78 ng/mL
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAMTSL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAMTSL2 purchase    MBS926864 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ADAMTS-like 2 (ADAMTSL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 ng/ml -200 ng/mL in biological research samples containing ADAMTSL2, with an estimated sensitivity of <0.78 ng/mL. The ELISA analytical biochemical technique of the MBS926864 kit is based on ADAMTSL2 antibody-ADAMTSL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTSL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTSL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ADAMTSL2 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ADAMTSL2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ADAMTSL2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ADAMTSL2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ADAMTSL2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of ADAMTSL2 elisa kit    ADAMTSL2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS926864. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ADAMTSL2. It may not necessarily be applicable to this product.
 NCBI GI #    223718260
 NCBI GeneID    9719
 NCBI Accession #    NP_001138792.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145320.1 [Other Products]
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 UniProt Primary Accession #    Q86TH1 [Other Products]
 UniProt Secondary Accession #    O60345; B1B0D5 [Other Products]
 UniProt Related Accession #    Q86TH1 [Other Products]
 Molecular Weight    104,621 Da
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 NCBI Official Full Name    ADAMTS-like protein 2
 NCBI Official Synonym Full Names    ADAMTS-like 2
 NCBI Official Symbol    ADAMTSL2 [Similar Products]
 NCBI Official Synonym Symbols   
GPHYSD1
[Similar Products]
 NCBI Protein Information    ADAMTS-like protein 2; ADAMTSL-2
 UniProt Protein Name    ADAMTS-like protein 2
 Protein Family    ADAMTS-like protein
 UniProt Gene Name    ADAMTSL2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0605; ADAMTSL-2 [Similar Products]
 UniProt Entry Name    ATL2_HUMAN
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 NCBI Summary for ADAMTSL2    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]
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 UniProt Comments for ADAMTSL2    ADAMTSL2: Defects in ADAMTSL2 are the cause of geleophysic dysplasia type 1 (GPHYSD1). An autosomal recessive disorder characterized by severe short stature, short hands and feet, joint limitations, and skin thickening. Radiologic features include delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and ovoid vertebral bodies. Affected individuals have characteristic facial features including a 'happy' face with full cheeks, shortened nose, hypertelorism, long and flat philtrum, and thin upper lip. Other distinctive features include progressive cardiac valvular thickening often leading to an early death, toe walking, tracheal stenosis, respiratory insufficiency, and lysosomal-like storage vacuoles in various tissues.

Protein type: Secreted; Protease; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: proteinaceous extracellular matrix

Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity

Biological Process: proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Geleophysic Dysplasia 1
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 Research Articles on ADAMTSL2    1. Two novel homozygous missense mutations in the ADAMTSL2 gene underlie geleophysic dysplasia in two consanguineous families from the United Arab Emirates.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ADAMTSL2 elisa kitOrgans/Tissues associated with ADAMTSL2 elisa kit
 Disease Name  Pubmed Publications
 GELEOPHYSIC DYSPLASIA 1 Antibodies  >7 publications with ADAMTSL2 and GELEOPHYSIC DYSPLASIA 1
 Bone Diseases Antibodies  >3 publications with ADAMTSL2 and Bone Diseases
 Hand Deformities, Congenital Antibodies  >2 publications with ADAMTSL2 and Hand Deformities, Congenital
 Growth Disorders Antibodies  >2 publications with ADAMTSL2 and Growth Disorders
 Geleophysic dwarfism Antibodies  >2 publications with ADAMTSL2 and Geleophysic dwarfism
 Respiratory Insufficiency Antibodies  >1 publications with ADAMTSL2 and Respiratory Insufficiency
 Hepatomegaly Antibodies  >1 publications with ADAMTSL2 and Hepatomegaly
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >4 publications with ADAMTSL2 and Connective Tissue
 Eye Antibodies  >2 publications with ADAMTSL2 and Eye
 Lung Antibodies  >2 publications with ADAMTSL2 and Lung
 Muscle Antibodies  >1 publications with ADAMTSL2 and Muscle
 Pancreas Antibodies  >1 publications with ADAMTSL2 and Pancreas
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