NP_001092102.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,383 Da
NCBI Official Full Name
proline-rich AKT1 substrate 1 isoform b
NCBI Official Synonym Full Names
AKT1 substrate 1 (proline-rich)
NCBI Official Synonym Symbols
NCBI Protein Information
proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate
UniProt Protein Name
Proline-rich AKT1 substrate 1
UniProt Synonym Protein Names
40 kDa proline-rich AKT substrate
UniProt Synonym Gene Names
UniProt Entry Name
AKTS1_HUMAN
NCBI Summary for AKT1S1
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
UniProt Comments for AKT1S1
Function: Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.3 PublicationsManual assertion based on experiment in:Ref.7
Research Articles on AKT1S1
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Products associated with AKT1S1 elisa kit
Pathways associated with AKT1S1 elisa kit
Diseases associated with AKT1S1 elisa kit
Organs/Tissues associated with AKT1S1 elisa kit
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