NP_054749.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,446 Da
NCBI Official Full Name
ARF GTPase-activating protein GIT1 isoform 2
NCBI Official Synonym Full Names
G protein-coupled receptor kinase interacting ArfGAP 1
NCBI Protein Information
ARF GTPase-activating protein GIT1; CAT1; CAT-1; ARF GAP GIT1; GRK-interacting protein 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-interactor 1; cool-associated and tyrosine-phosphorylated protein 1
UniProt Protein Name
ARF GTPase-activating protein GIT1
UniProt Synonym Protein Names
Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1
UniProt Synonym Gene Names
UniProt Entry Name
GIT1_HUMAN
UniProt Comments for GIT1
GIT1: a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK, and paxillin. Phosphorylation on Ser-709 increases its binding to paxillin and regulates cellular protrusions. Possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Functions as part of a multi-molecular signaling complex that regulates membrane protrusions and cell migration. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine kinase receptors (TKRs).
Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, ARF
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: focal adhesion; membrane; cytoplasm; cytosol
Molecular Function: protein binding; zinc ion binding
Biological Process: axon guidance; ephrin receptor signaling pathway; regulation of cytokinesis; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Research Articles on GIT1
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Products associated with GIT1 elisa kit
Pathways associated with GIT1 elisa kit
Diseases associated with GIT1 elisa kit
Organs/Tissues associated with GIT1 elisa kit
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