NP_003162.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,991 Da
NCBI Official Full Name
ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1
NCBI Official Synonym Full Names
suppressor of var1, 3-like 1 (S. cerevisiae)
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like protein 1; suppressor of var1, 3-like 1(SUV3)
UniProt Protein Name
ATP-dependent RNA helicase SUPV3L1, mitochondrial
UniProt Synonym Protein Names
Suppressor of var1 3-like protein 1; SUV3-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SUV3_HUMAN
UniProt Comments for SUPV3L1
SUPV3L1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Belongs to the helicase family.
Protein type: EC 3.6.4.13; Mitochondrial; DNA-binding; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: mitochondrion; mitochondrial matrix; nucleus
Molecular Function: DNA helicase activity; protein binding; protein homodimerization activity; DNA binding; RNA binding; double-stranded RNA binding; helicase activity; ATP-dependent RNA helicase activity; ATP binding
Biological Process: RNA catabolic process; positive regulation of cell growth; DNA duplex unwinding; DNA recombination; negative regulation of apoptosis
Research Articles on SUPV3L1
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Products associated with SUPV3L1 elisa kit
Diseases associated with SUPV3L1 elisa kit
Organs/Tissues associated with SUPV3L1 elisa kit
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