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KCNJ8 elisa kit :: Human ATP-sensitive inward rectifier potassium channel 8, KCNJ8 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2602682
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
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 Product Name   

ATP-sensitive inward rectifier potassium channel 8, KCNJ8, ELISA Kit

★Popular Item★
 Also Known As   

Human ATP-sensitive inward rectifier potassium channel 8, KCNJ8 ELISA Kit

 Product Gene Name   

KCNJ8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600935
 3D Structure    ModBase 3D Structure for Q15842
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 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant KCNJ8 concentration
 Assay Type    Sandwich
 Detection Range    100 ng/ml-1.56 ng/ml
 Sensitivity    0.5 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNJ8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNJ8 purchase    MBS2602682 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-sensitive inward rectifier potassium channel 8, KCNJ8, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 100 ng/ml-1.56 ng/ml in biological research samples containing KCNJ8, with an estimated sensitivity of 0.5 ng/ml. The ELISA analytical biochemical technique of the MBS2602682 kit is based on KCNJ8 antibody-KCNJ8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNJ8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNJ8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant KCNJ8 concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for KCNJ8 elisa kit

   Priciple of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human KCNJ8 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of KCNJ8 elisa kit    KCNJ8 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2602682. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KCNJ8. It may not necessarily be applicable to this product.
 NCBI GI #    4826802
 NCBI GeneID    3764
 NCBI Accession #    NP_004973.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004982.3 [Other Products]
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 UniProt Primary Accession #    Q15842 [Other Products]
 UniProt Secondary Accession #    O00657 [Other Products]
 UniProt Related Accession #    Q15842 [Other Products]
 Molecular Weight    47,968 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 8
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 8
 NCBI Official Symbol    KCNJ8 [Similar Products]
 NCBI Official Synonym Symbols   
KIR6.1; uKATP-1
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying subfamily J member 8
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 8
 UniProt Synonym Protein Names   
Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ8 [Similar Products]
 UniProt Entry Name    KCNJ8_HUMAN
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 NCBI Summary for KCNJ8    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]
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 UniProt Comments for KCNJ8    KCNJ8: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Defects in KCNJ8 may be associated with susceptibility to J-wave syndromes, a group of heart disorders characterized by early repolarization events as indicated by abnormal J-wave manifestation on electrocardiogram (ECG). The J point denotes the junction of the QRS complex and the ST segment on the ECG, marking the end of depolarization and the beginning of repolarization. An abnormal J wave is a deflection with a dome or hump morphology immediately following the QRS complex of the surface ECG. Examples of J-wave disorders are arrhythmias associated with an early repolarization pattern in the inferior or mid to lateral precordial leads, Brugada syndrome, some cases of idiopathic ventricular fibrillation (VF) with an early repolarization pattern in the inferior, inferolateral or global leads, as well as arrhythmias associated with hypothermia. Defects in KCNJ8 may be a cause of susceptibility to sudden infant death syndrome (SIDS). SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p11.23

Cellular Component: voltage-gated potassium channel complex; mitochondrion; myofibril; ATP-sensitive potassium channel complex; plasma membrane; sarcolemma

Molecular Function: G-protein activated inward rectifier potassium channel activity; ATP-activated inward rectifier potassium channel activity; sulfonylurea receptor binding; inward rectifier potassium channel activity; ATP binding

Biological Process: synaptic transmission; response to exogenous dsRNA; potassium ion import; heart development; response to lipopolysaccharide; kidney development; vasodilation; defense response to virus; potassium ion transport; response to pH
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 Research Articles on KCNJ8    1. KATP channels are up-regulated with increasing age in human myometrium
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNJ8 elisa kitPathways associated with KCNJ8 elisa kit
 Reference Product  PubMed Publications
 KCNJ11 elisa kit  >7 publications with KCNJ8 and KCNJ11
 ABCC9 elisa kit  >6 publications with KCNJ8 and ABCC9
 ABCC8 elisa kit  >5 publications with KCNJ8 and ABCC8
 KCNJ2 elisa kit  >1 publications with KCNJ8 and KCNJ2
 Products by Pathway  Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
Diseases associated with KCNJ8 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with KCNJ8 and Cardiovascular Diseases
 Heart Diseases Antibodies  >5 publications with KCNJ8 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >4 publications with KCNJ8 and Arrhythmias, Cardiac
 Myocardial Ischemia Antibodies  >3 publications with KCNJ8 and Myocardial Ischemia
 Nervous System Diseases Antibodies  >3 publications with KCNJ8 and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with KCNJ8 and Disease Models, Animal
 Genetic Predisposition to Disease Antibodies  >3 publications with KCNJ8 and Genetic Predisposition to Disease
 Ventricular Fibrillation Antibodies  >3 publications with KCNJ8 and Ventricular Fibrillation
 Pain Antibodies  >2 publications with KCNJ8 and Pain
 Brain Diseases Antibodies  >2 publications with KCNJ8 and Brain Diseases
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