NP_057613.4
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,242 Da
NCBI Official Full Name
phospholipid-transporting ATPase IB
NCBI Official Synonym Full Names
ATPase, aminophospholipid transporter, class I, type 8A, member 2
NCBI Protein Information
phospholipid-transporting ATPase IB; ATPase class I type 8A member 2; probable phospholipid-transporting ATPase IB; P4-ATPase flippase complex alpha subunit ATP8A2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
UniProt Protein Name
Phospholipid-transporting ATPase IB
UniProt Synonym Protein Names
ATPase class I type 8A member 2; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2
UniProt Synonym Gene Names
UniProt Entry Name
AT8A2_HUMAN
NCBI Summary for ATP8A2
The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ). In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
UniProt Comments for ATP8A2
ATP8A2 iso1: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.1; Transporter; Hydrolase; Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: Golgi apparatus; photoreceptor outer segment; integral to membrane; plasma membrane; endosome
Molecular Function: phospholipid-translocating ATPase activity; magnesium ion binding; ATP binding
Biological Process: skin development; inner ear morphogenesis; metabolic process; eating behavior; involuntary skeletal muscle contraction; positive regulation of multicellular organism growth; phospholipid translocation; negative regulation of cell proliferation; neuromuscular process controlling posture; axonogenesis; neurofilament cytoskeleton organization and biogenesis; detection of light stimulus involved in visual perception; neuron development; aging
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 4
Research Articles on ATP8A2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with ATP8A2 elisa kit
Diseases associated with ATP8A2 elisa kit
Organs/Tissues associated with ATP8A2 elisa kit
|