AAI30336.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,409 Da
NCBI Official Full Name
Activating transcription factor 2
NCBI Official Synonym Full Names
activating transcription factor 2
NCBI Official Synonym Symbols
HB16; CREB2; TREB7; CREB-2; CRE-BP1 [Similar Products]
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-2
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-2
UniProt Synonym Protein Names
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
UniProt Synonym Gene Names
CREB2; CREBP1; cAMP-dependent transcription factor ATF-2; CREB-2; cAMP-responsive element-binding protein 2 [Similar Products]
UniProt Entry Name
ATF2_HUMAN
NCBI Summary for ATF-2
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
UniProt Comments for ATF-2
ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.
Protein type: Transcription factor; EC 2.3.1.48; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2q32
Cellular Component: cytoplasm; mitochondrial outer membrane; nucleoplasm; nucleus
Molecular Function: cAMP response element binding protein binding; chromatin binding; histone acetyltransferase activity; metal ion binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity
Biological Process: establishment and/or maintenance of chromatin architecture; fat cell differentiation; histone acetylation; innate immune response; intra-S DNA damage checkpoint; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor-beta2 production; regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to osmotic stress; response to water deprivation; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter
Research Articles on ATF-2
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