AAB61900.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,124 Da
NCBI Official Full Name
activin receptor like kinase 1
NCBI Official Synonym Full Names
activin A receptor type II-like 1
NCBI Official Synonym Symbols
HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1 [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1
UniProt Protein Name
Serine/threonine-protein kinase receptor R3
UniProt Synonym Protein Names
Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
UniProt Synonym Gene Names
UniProt Entry Name
ACVL1_HUMAN
NCBI Summary for ALK1
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
UniProt Comments for ALK1
ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.
Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cell surface; cell soma; integral to plasma membrane; dendrite
Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; metal ion binding; activin binding; SMAD binding; protein kinase binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: protein heterooligomerization; blood circulation; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; negative regulation of cell adhesion; regulation of blood vessel endothelial cell migration; signal transduction; protein amino acid phosphorylation; BMP signaling pathway; negative regulation of cell proliferation; positive regulation of endothelial cell differentiation; negative regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; regulation of blood pressure; transforming growth factor beta receptor signaling pathway; lymphangiogenesis; angiogenesis; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of DNA replication; regulation of endothelial cell proliferation; in utero embryonic development; negative regulation of focal adhesion formation; negative regulation of blood vessel endothelial cell migration; blood vessel maturation; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of angiogenesis; positive regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; blood vessel remodeling; negative regulation of cell growth; wound healing, spreading of epidermal cells
Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2
Research Articles on ALK1
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Pathways associated with ALK1 elisa kit
Diseases associated with ALK1 elisa kit
Organs/Tissues associated with ALK1 elisa kit
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