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ACVR1B elisa kit :: Human Activin receptor type 1B (ACVR1B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7232818
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
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 Product Name   

Activin receptor type 1B (ACVR1B), ELISA Kit

★Popular Item★
 Also Known As   

Human Activin receptor type 1B (ACVR1B) ELISA Kit

 Product Gene Name   

ACVR1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601300
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of ACVR1B. No significant cross-reactivity or interference between ACVR1B and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between ACVR1B and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    0.5-10ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACVR1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACVR1B purchase    MBS7232818 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activin receptor type 1B (ACVR1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5-10ng/mL in biological research samples containing ACVR1B, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS7232818 kit is based on ACVR1B antibody-ACVR1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACVR1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACVR1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ACVR1B elisa kit

   Intended Uses||This ACVR1B ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human ACVR1B. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Principle of the Assay: ACVR1B ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-ACVR1B antibody and an ACVR1B-HRP conjugate. The assay sample and buffer are incubated together with ACVR1B-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the ACVR1B concentration since ACVR1B from samples and ACVR1B-HRP conjugate compete for the anti-ACVR1B antibody binding site. Since the number of sites is limited, as more sites are occupied by ACVR1B from the sample, fewer sites are left to bind ACVR1B-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The ACVR1B concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for ACVR1B elisa kit    Signal Transduction
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 Typical Testing Data/Standard Curve (for reference only) of ACVR1B elisa kit    ACVR1B elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS7232818. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACVR1B. It may not necessarily be applicable to this product.
 NCBI GI #    547775
 NCBI GeneID    91
 NCBI Accession #    P36896.1 [Other Products]
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 UniProt Secondary Accession #    Q15479; Q15480; Q15481; Q15482; B7Z5L8; B7Z5W5 [Other Products]
 UniProt Related Accession #    P36896 [Other Products]
 Molecular Weight    51,725 Da
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 NCBI Official Full Name    Activin receptor type-1B
 NCBI Official Synonym Full Names    activin A receptor, type IB
 NCBI Official Symbol    ACVR1B [Similar Products]
 NCBI Official Synonym Symbols   
ALK4; SKR2; ACTRIB; ACVRLK4
[Similar Products]
 NCBI Protein Information    activin receptor type-1B; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2
 UniProt Protein Name    Activin receptor type-1B
 UniProt Synonym Protein Names   
Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR1B [Similar Products]
 UniProt Synonym Gene Names    ACVRLK4; ALK4; ACTR-IB; ALK-4; SKR2 [Similar Products]
 UniProt Entry Name    ACV1B_HUMAN
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 NCBI Summary for ACVR1B    This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
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 UniProt Comments for ACVR1B    ALK4: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; activin receptor complex; receptor complex

Molecular Function: activin receptor activity; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; growth factor binding; ubiquitin protein ligase binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: development of primary female sexual characteristics; central nervous system development; in utero embryonic development; protein amino acid autophosphorylation; positive regulation of erythrocyte differentiation; activin receptor signaling pathway; peptidyl-threonine phosphorylation; signal transduction; protein amino acid phosphorylation; positive regulation of activin receptor signaling pathway; hair follicle development; regulation of transcription, DNA-dependent; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; G1/S transition of mitotic cell cycle
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 Research Articles on ACVR1B    1. Findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACVR1B elisa kitPathways associated with ACVR1B elisa kit
 Reference Product  PubMed Publications
 SMAD2 elisa kit  >35 publications with ACVR1B and SMAD2
 TDGF1 elisa kit  >18 publications with ACVR1B and TDGF1
 SMAD7 elisa kit  >3 publications with ACVR1B and SMAD7
 INHBB elisa kit  >2 publications with ACVR1B and INHBB
 INHBC elisa kit  >1 publications with ACVR1B and INHBC
 ACVR2B elisa kit  >1 publications with ACVR1B and ACVR2B
 ACVR2A elisa kit  >1 publications with ACVR1B and ACVR2A
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Diseases associated with ACVR1B elisa kitOrgans/Tissues associated with ACVR1B elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with ACVR1B and Cardiovascular Diseases
 Fibrosis Antibodies  >4 publications with ACVR1B and Fibrosis
 Nervous System Diseases Antibodies  >3 publications with ACVR1B and Nervous System Diseases
 Lung Diseases Antibodies  >3 publications with ACVR1B and Lung Diseases
 Brain Diseases Antibodies  >3 publications with ACVR1B and Brain Diseases
 Heart Failure Antibodies  >1 publications with ACVR1B and Heart Failure
 Kidney Diseases Antibodies  >1 publications with ACVR1B and Kidney Diseases
 Fever Antibodies  >1 publications with ACVR1B and Fever
 Inflammation Antibodies  >1 publications with ACVR1B and Inflammation
 Necrosis Antibodies  >1 publications with ACVR1B and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >15 publications with ACVR1B and Bone
 Embryonic Tissue Antibodies  >12 publications with ACVR1B and Embryonic Tissue
 Brain Antibodies  >10 publications with ACVR1B and Brain
 Muscle Antibodies  >7 publications with ACVR1B and Muscle
 Ovary Antibodies  >7 publications with ACVR1B and Ovary
 Blood Antibodies  >5 publications with ACVR1B and Blood
 Heart Antibodies  >5 publications with ACVR1B and Heart
 Lung Antibodies  >4 publications with ACVR1B and Lung
 Kidney Antibodies  >3 publications with ACVR1B and Kidney
 Skin Antibodies  >3 publications with ACVR1B and Skin
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