NP_001161221.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
169,750 Da
NCBI Official Full Name
adenylate cyclase type 10 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 10 (soluble)
NCBI Official Synonym Symbols
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a [Similar Products]
NCBI Protein Information
adenylate cyclase type 10
UniProt Protein Name
Adenylate cyclase type 10
UniProt Synonym Protein Names
AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase
UniProt Synonym Gene Names
UniProt Entry Name
ADCYA_HUMAN
NCBI Summary for ADCY10
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
UniProt Comments for ADCY10
SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.6.1.1; Lyase; Nucleotide Metabolism - purine; Adenylyl cyclase
Chromosomal Location of Human Ortholog: 1q24
Cellular Component: apical part of cell; axon; cell soma; cytoplasm; cytosol; dendrite; growth cone; microtubule cytoskeleton; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: adenylate cyclase activity; ATP binding; ATPase binding; magnesium ion binding; manganese ion binding
Biological Process: cAMP biosynthetic process; positive regulation of apoptosis; spermatogenesis
Disease: Hypercalciuria, Absorptive, 2
Research Articles on ADCY10
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Products associated with ADCY10 elisa kit
Pathways associated with ADCY10 elisa kit
Diseases associated with ADCY10 elisa kit
Organs/Tissues associated with ADCY10 elisa kit
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