AAC60642.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,420 Da
NCBI Official Full Name
adrenomedullin
NCBI Official Synonym Full Names
adrenomedullin
NCBI Official Synonym Symbols
NCBI Protein Information
ADM; preproadrenomedullin
UniProt Synonym Protein Names
ProAM N-terminal 20 peptide
UniProt Synonym Gene Names
UniProt Entry Name
ADML_HUMAN
NCBI Summary for AM
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
UniProt Comments for AM
ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: extracellular space; cytoplasm; extracellular region
Molecular Function: protein binding; adrenomedullin receptor binding; hormone activity; receptor binding
Biological Process: developmental growth; blood circulation; positive regulation of apoptosis; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; signal transduction; positive regulation of vasodilation; response to insulin stimulus; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; cell-cell signaling; receptor internalization; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; response to wounding; vasculogenesis; regulation of the force of heart contraction; aging; hormone secretion; progesterone biosynthetic process; organ regeneration; androgen metabolic process; neurite regeneration; positive regulation of heart rate; negative regulation of vasoconstriction; odontogenesis of dentine-containing teeth; response to starvation; positive regulation of angiogenesis; G-protein coupled receptor internalization; neural tube closure; negative regulation of vascular permeability; response to hypoxia; cAMP biosynthetic process; response to cold
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Products associated with AM elisa kit
Pathways associated with AM elisa kit
Diseases associated with AM elisa kit
Organs/Tissues associated with AM elisa kit
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