EAW87380.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,034 Da
NCBI Official Full Name
aminolevulinate, delta-, dehydratase, isoform CRA_a
NCBI Official Synonym Full Names
aminolevulinate dehydratase
NCBI Official Synonym Symbols
NCBI Protein Information
delta-aminolevulinic acid dehydratase; porphobilinogen synthase; aminolevulinate, delta-, dehydratase
UniProt Protein Name
Delta-aminolevulinic acid dehydratase
UniProt Synonym Protein Names
Porphobilinogen synthase
UniProt Synonym Gene Names
UniProt Entry Name
HEM2_HUMAN
NCBI Summary for ALAD
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]
UniProt Comments for ALAD
ALAD: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Defects in ALAD are the cause of acute hepatic porphyria (AHEPP). A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralysis, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors. Belongs to the ALADH family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lyase; EC 4.2.1.24
Chromosomal Location of Human Ortholog: 9q33.1
Cellular Component: nucleus; cytosol
Molecular Function: identical protein binding; porphobilinogen synthase activity; zinc ion binding; lead ion binding; catalytic activity
Biological Process: porphyrin metabolic process; protoporphyrinogen IX biosynthetic process; protein homooligomerization; heme biosynthetic process
Disease: Porphyria, Acute Hepatic
Research Articles on ALAD
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Products associated with ALAD elisa kit
Pathways associated with ALAD elisa kit
Diseases associated with ALAD elisa kit
Organs/Tissues associated with ALAD elisa kit
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