AAT69979.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
angiopoietin-2
NCBI Official Synonym Full Names
angiopoietin 2
NCBI Official Synonym Symbols
NCBI Protein Information
angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
UniProt Protein Name
Angiopoietin-2
UniProt Synonym Gene Names
UniProt Entry Name
ANGP2_HUMAN
NCBI Summary for ANGPT2
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ANGPT2
Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Ref.1 Ref.9 Ref.10 Ref.11
Subunit structure: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Ref.1 Ref.8 Ref.9 Ref.11
Subcellular location: Secreted.
Domain: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
Sequence similarities: Contains 1 fibrinogen C-terminal domain.
Research Articles on ANGPT2
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Products associated with ANGPT2 elisa kit
Pathways associated with ANGPT2 elisa kit
Diseases associated with ANGPT2 elisa kit
Organs/Tissues associated with ANGPT2 elisa kit
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