NP_001020527.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,102 Da
NCBI Official Full Name
anoctamin-6 isoform a
NCBI Official Synonym Full Names
anoctamin 6
NCBI Protein Information
anoctamin-6
UniProt Protein Name
Anoctamin-6
UniProt Synonym Protein Names
Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F
UniProt Synonym Gene Names
NCBI Summary for ANO6
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Comments for ANO6
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Research Articles on ANO6
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Products associated with ANO6 elisa kit
Pathways associated with ANO6 elisa kit
Diseases associated with ANO6 elisa kit
Organs/Tissues associated with ANO6 elisa kit
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