NP_001193674.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,063 Da
NCBI Official Full Name
thyroid peroxidase isoform b
NCBI Official Synonym Full Names
thyroid peroxidase
NCBI Protein Information
thyroid peroxidase; thyroperoxidase; thyroid microsomal antigen
UniProt Protein Name
Thyroid peroxidase
UniProt Synonym Gene Names
UniProt Entry Name
PERT_HUMAN
NCBI Summary for TPO
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
UniProt Comments for TPO
TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.11.1.8; Mitochondrial; Oxidoreductase; Membrane protein, integral; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; plasma membrane
Molecular Function: peroxidase activity; heme binding; iodide peroxidase activity; calcium ion binding
Biological Process: embryonic hemopoiesis; hydrogen peroxide catabolic process; thyroid hormone generation; response to oxidative stress; hormone biosynthetic process
Disease: Thyroid Dyshormonogenesis 2a
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Pathways associated with TPO elisa kit
Diseases associated with TPO elisa kit
Organs/Tissues associated with TPO elisa kit
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