CAG30252.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,847 Da
NCBI Official Full Name
ACR
NCBI Official Synonym Full Names
acrosin
NCBI Protein Information
acrosin; proacrosin; preproacrosin; acrosin light and heavy chain prepropeptide
UniProt Protein Name
Acrosin
UniProt Synonym Gene Names
UniProt Entry Name
ACRO_HUMAN
NCBI Summary for ACR-Ab
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
UniProt Comments for ACR-Ab
ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family.
Protein type: Protease; EC 3.4.21.10
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: protein complex; extracellular region; Golgi-associated vesicle; nucleus; acrosomal matrix
Molecular Function: mannose binding; protein binding; copper ion binding; amidase activity; DNA binding; zinc ion binding; serine-type endopeptidase activity; drug binding; fucose binding
Biological Process: response to steroid hormone stimulus; binding of sperm to zona pellucida; single fertilization; adenylate cyclase activation; acrosome reaction; penetration of zona pellucida; acrosome matrix dispersal; multicellular organism reproduction
Research Articles on ACR-Ab
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Pathways associated with ACR-Ab elisa kit
Diseases associated with ACR-Ab elisa kit
Organs/Tissues associated with ACR-Ab elisa kit
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