NP_000036.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,356 Da
NCBI Official Full Name
arginase-1 isoform 2
NCBI Official Synonym Full Names
arginase 1
NCBI Protein Information
arginase-1
UniProt Protein Name
Arginase-1
UniProt Synonym Protein Names
Liver-type arginase; Type I arginase
UniProt Entry Name
ARGI1_HUMAN
NCBI Summary for ARG1
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for ARG1
ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; EC 3.5.3.1; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: 6q23
Cellular Component: cell soma; cytoplasm; cytosol; extracellular space; mitochondrial outer membrane; neuron projection; nucleus
Molecular Function: arginase activity; manganese ion binding
Biological Process: aging; arginine catabolic process; arginine catabolic process to ornithine; collagen biosynthetic process; liver development; lung development; mammary gland involution; maternal process involved in pregnancy; polyamine metabolic process; positive regulation of endothelial cell proliferation; response to amine stimulus; response to amino acid stimulus; response to axon injury; response to cadmium ion; response to drug; response to herbicide; response to manganese ion; response to methylmercury; response to selenium ion; response to vitamin A; response to vitamin E; response to zinc ion; urea cycle
Disease: Argininemia
Research Articles on ARG1
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Products associated with ARG1 elisa kit
Pathways associated with ARG1 elisa kit
Diseases associated with ARG1 elisa kit
Organs/Tissues associated with ARG1 elisa kit
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