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NPR1 elisa kit :: Human Atrial natriuretic peptide receptor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2884746 NPR1 elisa kit
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Atrial natriuretic peptide receptor 1 (NPR1), ELISA Kit

★Popular Item★
 Also Known As   

Human Atrial natriuretic peptide receptor 1 ELISA Kit

 Product Synonym Names    Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A; NPR1; ANPRA; 4.6.1.2
 Product Gene Name   

NPR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    108960
 3D Structure    ModBase 3D Structure for P16066
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 Species Reactivity    Human
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 Assay Type    Sandwich
 Detection Range    0.312-20 ng/mL
 Sensitivity    0.15 ng/mL
 Intra-Assay CV    <=4.7%
 Inter-Assay CV    <=7.9%
 Recovery    93%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NPR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NPR1 purchase    MBS2884746 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Atrial natriuretic peptide receptor 1 (NPR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312-20 ng/mL in biological research samples containing NPR1, with an estimated sensitivity of 0.15 ng/mL. The ELISA analytical biochemical technique of the MBS2884746 kit is based on NPR1 antibody-NPR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NPR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NPR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for NPR1. It may not necessarily be applicable to this product.
 NCBI GI #    167830411
 NCBI GeneID    4881
 NCBI Accession #    NP_000897.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000906.3 [Other Products]
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 UniProt Primary Accession #    P16066 [Other Products]
 UniProt Secondary Accession #    Q5SR08; Q6P4Q3; B0ZBF0 [Other Products]
 UniProt Related Accession #    P16066 [Other Products]
 Molecular Weight    118,919 Da
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 NCBI Official Full Name    atrial natriuretic peptide receptor 1
 NCBI Official Synonym Full Names    natriuretic peptide receptor 1
 NCBI Official Symbol    NPR1 [Similar Products]
 NCBI Official Synonym Symbols   
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
[Similar Products]
 NCBI Protein Information    atrial natriuretic peptide receptor 1
 UniProt Protein Name    Atrial natriuretic peptide receptor 1
 UniProt Synonym Protein Names   
Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
 Protein Family    Atrial natriuretic peptide receptor
 UniProt Gene Name    NPR1 [Similar Products]
 UniProt Synonym Gene Names    ANPRA; ANP-A; ANPR-A; NPR-A; GC-A [Similar Products]
 UniProt Entry Name    ANPRA_HUMAN
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 NCBI Summary for NPR1    Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
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 UniProt Comments for NPR1    ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.

Protein type: Lyase; Guanylyl cyclase; Protein kinase, dual-specificity (receptor); Receptor, misc.; Membrane protein, integral; Protein kinase, RGC; Nucleotide Metabolism - purine; EC 4.6.1.2; Kinase, protein; RGC group; RGC family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein kinase activity; protein kinase binding

Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; dopamine metabolic process; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP biosynthetic process; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation
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 Research Articles on NPR1    1. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NPR1 elisa kitPathways associated with NPR1 elisa kit
 Reference Product  PubMed Publications
 NPPA elisa kit  >9 publications with NPR1 and NPPA
 NPPB elisa kit  >8 publications with NPR1 and NPPB
 Products by Pathway  Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Physiological Factors Pathway antibodies  Physiological Factors Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Regulation Of Lipolysis In Adipocytes Pathway antibodies  Regulation Of Lipolysis In Adipocytes Pathway Diagram
Diseases associated with NPR1 elisa kitOrgans/Tissues associated with NPR1 elisa kit
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >23 publications with NPR1 and Hypertension
 Hypertrophy Antibodies  >21 publications with NPR1 and Hypertrophy
 Heart Diseases Antibodies  >20 publications with NPR1 and Heart Diseases
 Necrosis Antibodies  >15 publications with NPR1 and Necrosis
 Fibrosis Antibodies  >14 publications with NPR1 and Fibrosis
 Cardiomegaly Antibodies  >13 publications with NPR1 and Cardiomegaly
 Heart Failure Antibodies  >11 publications with NPR1 and Heart Failure
 Inflammation Antibodies  >8 publications with NPR1 and Inflammation
 Weight Loss Antibodies  >3 publications with NPR1 and Weight Loss
 Pain Antibodies  >3 publications with NPR1 and Pain
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >31 publications with NPR1 and Heart
 Brain Antibodies  >24 publications with NPR1 and Brain
 Muscle Antibodies  >18 publications with NPR1 and Muscle
 Kidney Antibodies  >18 publications with NPR1 and Kidney
 Vascular Antibodies  >18 publications with NPR1 and Vascular
 Embryonic Tissue Antibodies  >5 publications with NPR1 and Embryonic Tissue
 Lung Antibodies  >4 publications with NPR1 and Lung
 Connective Tissue Antibodies  >2 publications with NPR1 and Connective Tissue
 Nerve Antibodies  >2 publications with NPR1 and Nerve
 Adipose Tissue Antibodies  >2 publications with NPR1 and Adipose Tissue
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