AAI12031.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
18,864 Da
NCBI Official Full Name
BAFF receptor
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13C
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 13C
UniProt Synonym Protein Names
B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3
UniProt Synonym Gene Names
UniProt Entry Name
TR13C_HUMAN
NCBI Summary for BAFFR
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
UniProt Comments for BAFFR
BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Cell cycle regulation; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 22q13.1-q13.31
Cellular Component: integral to membrane; external side of plasma membrane
Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process
Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
Research Articles on BAFFR
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Products associated with BAFFR elisa kit
Pathways associated with BAFFR elisa kit
Diseases associated with BAFFR elisa kit
Organs/Tissues associated with BAFFR elisa kit
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