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B7-H3 elisa kit :: Human B7-H3 Gene ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021298 B7-H3 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B7-H3 Gene, ELISA Kit

 Also Known As   

Human B7-H3 Gene ELISA Kit

 Product Gene Name   

B7-H3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 15; NC_000015.9 (73976622..74006859). Location: 15q23-q24
 OMIM    605715
 3D Structure    ModBase 3D Structure for Q5ZPR3
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 Species Reactivity    Human
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of B7-H3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for B7-H3 purchase    MBS021298 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B7-H3 Gene, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing B7-H3. The ELISA analytical biochemical technique of the MBS021298 kit is based on B7-H3 antibody-B7-H3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect B7-H3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, B7-H3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for B7-H3. It may not necessarily be applicable to this product.
 NCBI GI #    52694705
 NCBI GeneID    80381
 NCBI Accession #    CAE47548.1 [Other Products]
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 UniProt Primary Accession #    Q5ZPR3 [Other Products]
 UniProt Secondary Accession #    Q6P5Y4; Q6UXI2; Q8NBI8; Q8NC34; Q8NCB6; Q9BXR1 [Other Products]
 UniProt Related Accession #    Q5ZPR3 [Other Products]
 Molecular Weight    57,235 Da
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 NCBI Official Full Name    B7-H3 protein
 NCBI Official Synonym Full Names    CD276 molecule
 NCBI Official Symbol    CD276 [Similar Products]
 NCBI Official Synonym Symbols   
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
[Similar Products]
 NCBI Protein Information    CD276 antigen; B7 homolog 3; costimulatory molecule
 UniProt Protein Name    CD276 antigen
 UniProt Synonym Protein Names   
4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule
 UniProt Gene Name    CD276 [Similar Products]
 UniProt Synonym Gene Names    B7H3; B7-H3 [Similar Products]
 UniProt Entry Name    CD276_HUMAN
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 NCBI Summary for B7-H3    The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for B7-H3    CD276: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell proliferation; positive regulation of osteoblast differentiation; regulation of immune response; negative regulation of T cell proliferation; T cell activation; negative regulation of inflammatory response; negative regulation of interleukin-2 biosynthetic process; positive regulation of T cell proliferation; immune response; positive regulation of bone mineralization; positive regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma biosynthetic process
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 Research Articles on B7-H3    1. Data suggest that the immunomodulatory proteins B7-H1, B7-H3, and HLA-G5 are secreted from early and term placenta via exosomes and have important implications in mechanisms by which trophoblast immunomodulators modify maternal immunological milieu.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with B7-H3 elisa kitPathways associated with B7-H3 elisa kit
 Reference Product  PubMed Publications
 CD4 elisa kit  >17 publications with B7-H3 and CD4
 CD28 elisa kit  >17 publications with B7-H3 and CD28
 CTLA4 elisa kit  >9 publications with B7-H3 and CTLA4
 CD40 elisa kit  >5 publications with B7-H3 and CD40
 CD40LG elisa kit  >1 publications with B7-H3 and CD40LG
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with B7-H3 elisa kitOrgans/Tissues associated with B7-H3 elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >19 publications with B7-H3 and Immune System Diseases
 Disease Models, Animal Antibodies  >10 publications with B7-H3 and Disease Models, Animal
 Necrosis Antibodies  >8 publications with B7-H3 and Necrosis
 Inflammation Antibodies  >8 publications with B7-H3 and Inflammation
 Liver Neoplasms Antibodies  >7 publications with B7-H3 and Liver Neoplasms
 Liver Diseases Antibodies  >7 publications with B7-H3 and Liver Diseases
 Prostatic Diseases Antibodies  >7 publications with B7-H3 and Prostatic Diseases
 Genital Diseases, Male Antibodies  >7 publications with B7-H3 and Genital Diseases, Male
 Breast Neoplasms Antibodies  >6 publications with B7-H3 and Breast Neoplasms
 Lung Neoplasms Antibodies  >6 publications with B7-H3 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with B7-H3 and Liver
 Lung Antibodies  >9 publications with B7-H3 and Lung
 Brain Antibodies  >9 publications with B7-H3 and Brain
 Bone Antibodies  >7 publications with B7-H3 and Bone
 Prostate Antibodies  >7 publications with B7-H3 and Prostate
 Heart Antibodies  >5 publications with B7-H3 and Heart
 Skin Antibodies  >4 publications with B7-H3 and Skin
 Kidney Antibodies  >4 publications with B7-H3 and Kidney
 Pancreas Antibodies  >3 publications with B7-H3 and Pancreas
 Embryonic Tissue Antibodies  >3 publications with B7-H3 and Embryonic Tissue
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