NP_066551.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,670 Da
NCBI Official Full Name
bone morphogenetic protein 5 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 5
NCBI Protein Information
bone morphogenetic protein 5; BMP-5; bone morphogenenic protein-5
UniProt Protein Name
Bone morphogenetic protein 5
UniProt Synonym Gene Names
UniProt Entry Name
BMP5_HUMAN
NCBI Summary for BMP-5
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP-5
BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: extracellular space
Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: ossification; negative regulation of insulin-like growth factor receptor signaling pathway; pattern specification process; BMP signaling pathway; regulation of apoptosis; negative regulation of cell proliferation; cartilage development; regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; positive regulation of epithelial cell proliferation; growth
Research Articles on BMP-5
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Products associated with BMP-5 elisa kit
Pathways associated with BMP-5 elisa kit
Diseases associated with BMP-5 elisa kit
Organs/Tissues associated with BMP-5 elisa kit
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