NP_001303892.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,746 Da
NCBI Official Full Name
probetacellulin isoform 2
NCBI Official Synonym Full Names
betacellulin
NCBI Protein Information
probetacellulin
UniProt Protein Name
Probetacellulin
UniProt Synonym Gene Names
NCBI Summary for BTC
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]
UniProt Comments for BTC
BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Protein type: Cell cycle regulation; Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular region; extracellular space; integral component of membrane; intracellular; plasma membrane
Molecular Function: epidermal growth factor receptor binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; MAPK cascade; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of mitotic nuclear division; regulation of phosphatidylinositol 3-kinase signaling
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Pathways associated with BTC elisa kit
Diseases associated with BTC elisa kit
Organs/Tissues associated with BTC elisa kit
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