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BMP-15 elisa kit :: Human Bone Morphogenetic Protein 15 (BMP-15) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS261936
Typical Testing Data/Standard Curve
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
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 Product Name   

Bone Morphogenetic Protein 15 (BMP-15), ELISA Kit

★Popular Item★
 Also Known As   

Human Bone Morphogenetic Protein 15 (BMP-15) ELISA Kit

 Product Gene Name   

BMP-15 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 300510
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 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant BMP-15 concentration.
 Assay Type    Sandwich
 Detection Range    2000 pg/ml-31.2 pg/ml
 Sensitivity    12 pg/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BMP-15 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BMP-15 purchase    MBS261936 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein 15 (BMP-15) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 2000 pg/ml-31.2 pg/ml in biological research samples containing BMP-15, with an estimated sensitivity of 12 pg/ml. The ELISA analytical biochemical technique of the MBS261936 kit is based on BMP-15 antibody-BMP-15 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMP-15 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMP-15. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant BMP-15 concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for BMP-15 elisa kit

   Principle of the Assay||This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human BMP-15 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve of BMP-15 elisa kit    BMP-15 elisa kit Typical Testing Data/Standard Curve image
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Sample Manual Insert of MBS261936. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BMP-15. It may not necessarily be applicable to this product.
 NCBI GI #    257743454
 NCBI GeneID    9210
 NCBI Accession #    NP_005439.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005448.2 [Other Products]
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 UniProt Secondary Accession #    Q17RM6; Q5JST1; Q9UMS1 [Other Products]
 UniProt Related Accession #    O95972 [Other Products]
 Molecular Weight    45,055 Da
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 NCBI Official Full Name    bone morphogenetic protein 15
 NCBI Official Synonym Full Names    bone morphogenetic protein 15
 NCBI Official Symbol    BMP15 [Similar Products]
 NCBI Official Synonym Symbols   
ODG2; POF4; GDF9B
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 15; BMP-15; GDF-9B; growth/differentiation factor 9B
 UniProt Protein Name    Bone morphogenetic protein 15
 UniProt Synonym Protein Names   
Growth/differentiation factor 9B; GDF-9B
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP15 [Similar Products]
 UniProt Synonym Gene Names    GDF9B; BMP-15; GDF-9B [Similar Products]
 UniProt Entry Name    BMP15_HUMAN
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 NCBI Summary for BMP-15    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]
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 UniProt Comments for BMP-15    BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; ovarian follicle development; granulosa cell development; regulation of MAPKKK cascade; positive regulation of transcription, DNA-dependent; female gamete generation; cell development

Disease: Ovarian Dysgenesis 2
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 Research Articles on BMP-15    1. BMP15 down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3-mediated SMAD1/5/8 signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP-15 elisa kitPathways associated with BMP-15 elisa kit
 Reference Product  PubMed Publications
 GDF9 elisa kit  >292 publications with BMP-15 and GDF9
 BMPR2 elisa kit  >34 publications with BMP-15 and BMPR2
 BMPR1B elisa kit  >18 publications with BMP-15 and BMPR1B
 FSHR elisa kit  >13 publications with BMP-15 and FSHR
 NOBOX elisa kit  >5 publications with BMP-15 and NOBOX
 FIGLA elisa kit  >5 publications with BMP-15 and FIGLA
 FGF7 elisa kit  >2 publications with BMP-15 and FGF7
 DIAPH2 elisa kit  >1 publications with BMP-15 and DIAPH2
 POF1B elisa kit  >1 publications with BMP-15 and POF1B
 Products by Pathway  Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
Diseases associated with BMP-15 elisa kit
 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >55 publications with BMP-15 and Infertility, Female
 Neoplasms Antibodies  >13 publications with BMP-15 and Neoplasms
 Polycystic Ovary Syndrome Antibodies  >12 publications with BMP-15 and Polycystic Ovary Syndrome
 Urogenital Abnormalities Antibodies  >8 publications with BMP-15 and Urogenital Abnormalities
 Necrosis Antibodies  >4 publications with BMP-15 and Necrosis
 Abnormalities, Drug-Induced Antibodies  >2 publications with BMP-15 and Abnormalities, Drug-Induced
 Weight Loss Antibodies  >2 publications with BMP-15 and Weight Loss
 Immune System Diseases Antibodies  >2 publications with BMP-15 and Immune System Diseases
 Hyperplasia Antibodies  >1 publications with BMP-15 and Hyperplasia
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