NP_055297.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,047 Da
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Protein Information
bone morphogenetic protein 10
UniProt Protein Name
Bone morphogenetic protein 10
UniProt Synonym Gene Names
NCBI Summary for BMP10
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
UniProt Comments for BMP10
BMP10: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Belongs to the TGF-beta family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; Z disc
Molecular Function: cytokine activity; hormone activity; protein binding; receptor serine/threonine kinase binding; telethonin binding; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; adult heart development; atrial cardiac muscle morphogenesis; BMP signaling pathway; cardiac muscle cell proliferation; negative regulation of cell growth; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; sarcomere organization; ventricular cardiac muscle cell development; ventricular cardiac muscle morphogenesis
Research Articles on BMP10
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Pathways associated with BMP10 elisa kit
Diseases associated with BMP10 elisa kit
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