BAA32250.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,482 Da
NCBI Official Full Name
CAD
NCBI Official Synonym Full Names
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
NCBI Protein Information
DNA fragmentation factor subunit beta; DNA fragmentation factor 40 kDa subunit; caspase-activated DNase; caspase-activated deoxyribonuclease; caspase-activated nuclease
UniProt Protein Name
DNA fragmentation factor subunit beta
UniProt Synonym Protein Names
Caspase-activated deoxyribonuclease; CAD; Caspase-activated DNase; Caspase-activated nuclease; CPAN; DNA fragmentation factor 40 kDa subunit; DFF-40
UniProt Synonym Gene Names
UniProt Entry Name
DFFB_HUMAN
NCBI Summary for CAD
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]
UniProt Comments for CAD
DFFB: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Deoxyribonuclease; Apoptosis; EC 3.-.-.-
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: nucleoplasm; nuclear chromatin; nucleolus; cytosol; nucleus
Molecular Function: enzyme binding; deoxyribonuclease activity
Biological Process: apoptosis; DNA fragmentation during apoptosis; apoptotic chromosome condensation; cell structure disassembly during apoptosis
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Products associated with CAD elisa kit
Pathways associated with CAD elisa kit
Diseases associated with CAD elisa kit
Organs/Tissues associated with CAD elisa kit
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