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CCR2 elisa kit :: Human CCR2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2516082
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCR2, ELISA Kit

★Popular Item★
 Also Known As   

Human CCR2 (Chemokine C-C-Motif Receptor 2) ELISA Kit

 Product Gene Name   

CCR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2516082 COA    COA PDF
 OMIM    601267
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanCCR2. No significant cross-reactivity or interference between HumanCCR2 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CCR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CCR2 purchase    MBS2516082 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CCR2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing CCR2, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2516082 kit is based on CCR2 antibody-CCR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CCR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CCR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CCR2 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanCCR2concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CCR2. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CCR2and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CCR2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CCR2.You can calculate the concentration of CCR2in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CCR2 elisa kit    CCR2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2516082. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CCR2. It may not necessarily be applicable to this product.
 NCBI GI #    1168965
 NCBI GeneID    729230
 NCBI Accession #    P41597.1 [Other Products]
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 UniProt Secondary Accession #    Q4VBL2; A0AVQ3; B2RMT0 [Other Products]
 UniProt Related Accession #    P41597 [Other Products]
 Molecular Weight    41,064 Da
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 NCBI Official Full Name    C-C chemokine receptor type 2
 NCBI Official Synonym Full Names    chemokine (C-C motif) receptor 2
 NCBI Official Symbol    CCR2 [Similar Products]
 NCBI Official Synonym Symbols   
CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
[Similar Products]
 NCBI Protein Information    C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
 UniProt Protein Name    C-C chemokine receptor type 2
 UniProt Synonym Protein Names   
Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192
 Protein Family    C-C chemokine receptor
 UniProt Gene Name    CCR2 [Similar Products]
 UniProt Synonym Gene Names    CMKBR2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; MCP-1-R [Similar Products]
 UniProt Entry Name    CCR2_HUMAN
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 NCBI Summary for CCR2    This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for CCR2    CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; integral to plasma membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol

Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; innate immune response; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of inflammatory response
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 Research Articles on CCR2    1. Unique properties of human beta-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCR2 elisa kitPathways associated with CCR2 elisa kit
 Reference Product  PubMed Publications
 CCL2 elisa kit  >1240 publications with CCR2 and CCL2
 CCL5 elisa kit  >226 publications with CCR2 and CCL5
 CXCL12 elisa kit  >158 publications with CCR2 and CXCL12
 CCL7 elisa kit  >92 publications with CCR2 and CCL7
 CCL11 elisa kit  >48 publications with CCR2 and CCL11
 CCL8 elisa kit  >48 publications with CCR2 and CCL8
 CCL13 elisa kit  >27 publications with CCR2 and CCL13
 CCL22 elisa kit  >16 publications with CCR2 and CCL22
 CCL16 elisa kit  >7 publications with CCR2 and CCL16
 JAK2 elisa kit  >5 publications with CCR2 and JAK2
 Products by Pathway  Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with CCR2 elisa kitOrgans/Tissues associated with CCR2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >858 publications with CCR2 and Inflammation
 Immune System Diseases Antibodies  >552 publications with CCR2 and Immune System Diseases
 Disease Models, Animal Antibodies  >377 publications with CCR2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >343 publications with CCR2 and Cardiovascular Diseases
 Necrosis Antibodies  >247 publications with CCR2 and Necrosis
 Atherosclerosis Antibodies  >209 publications with CCR2 and Atherosclerosis
 Lung Diseases Antibodies  >177 publications with CCR2 and Lung Diseases
 Fibrosis Antibodies  >117 publications with CCR2 and Fibrosis
 Kidney Diseases Antibodies  >108 publications with CCR2 and Kidney Diseases
 Liver Diseases Antibodies  >100 publications with CCR2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1410 publications with CCR2 and Blood
 Bone Marrow Antibodies  >261 publications with CCR2 and Bone Marrow
 Brain Antibodies  >259 publications with CCR2 and Brain
 Spleen Antibodies  >98 publications with CCR2 and Spleen
 Connective Tissue Antibodies  >67 publications with CCR2 and Connective Tissue
 Intestine Antibodies  >55 publications with CCR2 and Intestine
 Prostate Antibodies  >34 publications with CCR2 and Prostate
 Thymus Antibodies  >26 publications with CCR2 and Thymus
 Mouth Antibodies  >19 publications with CCR2 and Mouth
 Placenta Antibodies  >8 publications with CCR2 and Placenta
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